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A particularly challenging use of decision-theoretic models in economics is to forecast the impact of large changes in the environment. The problem we explore in this article is how to gain confidence in a model's ability to predict the impact of such large changes. We show that an approach to validation and model selection that includes the choice of a “nonrandom holdout sample,” a sample that differs significantly from the estimation sample along the policy dimension that the model is meant to forecast, can be fruitful.