A proliferating literature in IR theory documents the impact of transnational advocacy networks on global public policy making. We know little, however, about the process by which advocacy networks select issues around which to mobilize in the first place. This paper aims to develop a framework for analyzing variation in issue emergence by comparing two prominent issues in the transnational network around children and armed conflict (child soldiers and girls in war) to an issue absent from this advocacy sphere (the protection needs of children born as a result of wartime rape). This variation is not easily explained by extant hypotheses about issue emergence, which suggests the need for rigorous research on both positive and negative outcomes in global agenda setting. I conclude with several suggestions toward that end.