• cognitive mediation;
  • cognitive processes;
  • psychotherapy

Greater knowledge of the mechanisms underlying cognitive change in the context of depression is an important goal of current clinical research. The thoughtful review by Garratt, Ingram, Rand, and Sawalani (2007) highlights the wealth of research that has been conducted in this area, while also drawing attention to the many complexities inherent in studying the cognitive mediation hypothesis in cognitive therapy. In this commentary, we use the review by Garratt et al. as a starting point from which to highlight some of the issues that we believe to be imperative to the advancement of knowledge in this field of research. These issues include the need for strong connections between theories of cognitive mediation and depression, the deployment of appropriate research paradigms and methods to advance the field, and the conduct of research in contexts that are relevant to clinical practice.