Characteristics of menstrual and nonmenstrual attacks in women with menstrually related migraine referred to headache centres

Authors

  • F Granella,

    Corresponding author
    1. Department of Neurosciences, Neurology Unit, University of Parma, Parma,
      Dr Franco Granella, Dipartimento di Neuroscienze, Sezione di Neurologia, Università di Parma, Strada del Quartiere, 4, 43100 Parma, Italy. Tel. +39 0521 70 26 95, fax +39 0521 28 27 76, e-mail granella@unipr.it
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  • G Sances,

    1. Headache Centre, Institute of Neurology, IRCCS ‘C. Mondino’ Foundation, Paiva
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  • G Allais,

    1. Woman's Headache Centre, Department of Obstetrics and Gynaecology, University of Turin, Turin,
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  • RE Nappi,

    1. University Centre for Adaptive Disorders and Headache, University of Pavia, Pavia and University of Modena and Reggio Emilia, Modena,
    2. Department of Obstetrics and Gynaecology, IRCCS ‘Policlinico S. Matteo’, University of Pavia, Pavia and
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  • A Tirelli,

    1. Mother-Infant Department, University of Modena and Reggio Emilia, Modena,
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  • C Benedetto,

    1. Woman's Headache Centre, Department of Obstetrics and Gynaecology, University of Turin, Turin,
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  • B Brundu,

    1. Department of Obstetrics and Gynaecology, IRCCS ‘Policlinico S. Matteo’, University of Pavia, Pavia and
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  • F Facchinetti,

    1. University Centre for Adaptive Disorders and Headache, University of Pavia, Pavia and University of Modena and Reggio Emilia, Modena,
    2. Mother-Infant Department, University of Modena and Reggio Emilia, Modena,
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  • G Nappi

    1. Headache Centre, Institute of Neurology, IRCCS ‘C. Mondino’ Foundation, Paiva
    2. University Centre for Adaptive Disorders and Headache, University of Pavia, Pavia and University of Modena and Reggio Emilia, Modena,
    3. Institute of Nervous and Mental Diseases, University of Rome ‘La Sapienza’, Rome, Italy
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Dr Franco Granella, Dipartimento di Neuroscienze, Sezione di Neurologia, Università di Parma, Strada del Quartiere, 4, 43100 Parma, Italy. Tel. +39 0521 70 26 95, fax +39 0521 28 27 76, e-mail granella@unipr.it

Abstract

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Aim of this study was to determine whether menstrual attacks differ from nonmenstrual attacks (NMA) as regards clinical features or response to abortive treatment in women affected by menstrually related migraine (MRM) referred to tertiary care centres. Sixty-four women with MRM were enrolled in a 2-month diary study. Perimenstrual attacks were split into three groups – premenstrual (PMA), menstrual (MA) and late menstrual (LMA) – and compared to nonmenstrual ones. Perimenstrual attacks were significantly longer than NMA. No other migraine attack features were found to differ between the various phases of the cycle. Migraine work-related disability was significantly greater in PMA and MA than in NMA. Acute attack treatment was less effective in perimenstrual attacks. Pain-free at 2 h after dosage was achieved in 13.5% of MA (OR 0.41; 95% CI 0.22, 0.76) vs. 32.9% of NMA. We concluded that, in MRM, perimenstrual attacks are longer and less responsive to acute attack treatment than NMA.

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