Migraine and adiponectin: is there a connection?



This article is corrected by:

  1. Errata: ERRATUM Volume 27, Issue 6, 570, Article first published online: 29 May 2007

B.L. Peterlin, Drexel University College of Medicine, Department of Neurology, 245 N. 15th Street, Mail Stop 423, Philadelphia, PA 19102, USA Tel. + 1 215 762 1267, fax + 1 215 762 1409, e-mail lee.peterlin@drexelmed.edu


Peterlin BL, Bigal M, Tepper S, Urakaze M & Rapoport A. Migraine and adiponectin: is there a connection? Cephalalgia 2007; 27:435–446. London. ISSB 0333-1024

Migraine is a common disorder, characterized by recurrent episodes of headache and associated symptoms. The full pathophysiology of migraine is incompletely delineated. Current theories suggest that it is a neurovascular disorder involving cortical depression, neurogenic inflammation and vasodilation. Various neuropeptides and cytokines have been implicated in the pathophysiology of migraine including calcitonin gene-related peptide, interleukin (IL)-1, IL-6 and tumour necrosis factor (TNF)-α. There is evidence demonstrating an association between migraine and processes associated with inflammation, atherosclerosis, immunity and insulin sensitivity. Similarly, adiponectin, an adipocytokine secreted by adipose tissue, has protective roles against the development of insulin resistance, dyslipidaemia and atherosclerosis and exhibits anti-inflammatory properties. The anti-inflammatory activities of adiponectin include inhibition of IL-6 and TNF-induced IL-8 formation, as well as induction of the anti-inflammatory cytokines IL-10 and IL-1 receptor antagonist. Adiponectin levels are also inversely correlated with C-reactive protein (CRP), TNF-α and IL-6 levels. Likewise, recent studies have shown a possible correlation between CRP, TNF-α and IL-6 and migraine attacks. In addition, insulin sensitivity is impaired in migraine and obesity is a risk factor for the transformation from episodic to chronic migraine. In this review we discuss the basic science of adiponectin and its potential connection to the pathophysiology of migraine. Future research may focus on how adiponectin levels are potentially altered during migraine attacks, and how that information can be potentially translated into migraine therapy.