Epidemiology of orofacial herpes simplex virus infections in the general population in France: results of the HERPIMAX study
Article first published online: 22 JUN 2007
Journal of the European Academy of Dermatology and Venereology
Volume 21, Issue 10, pages 1398–1403, November 2007
How to Cite
Malvy, D., Ezzedine, K., Lançon, F., Halioua, B., Rezvani, A., Bertrais, S., Chanzy, B., Malkin, J.-E., Morand, P., De Labareyre, C., Hercberg, S. and El Hasnaoui, A. (2007), Epidemiology of orofacial herpes simplex virus infections in the general population in France: results of the HERPIMAX study. Journal of the European Academy of Dermatology and Venereology, 21: 1398–1403. doi: 10.1111/j.1468-3083.2007.02302.x
- Issue published online: 22 JUN 2007
- Article first published online: 22 JUN 2007
- Received: 6 March 2007, accepted 20 March 2007
- herpes simplex virus;
- orofacial herpes;
Background Prevalence of clinically manifest orofacial herpes in the general population is poorly characterized.
Objectives To establish the lifetime prevalence of clinically manifest orofacial herpes and its relationship with herpes simplex virus (HSV) serotype in the French general population.
Patients/methods Subjects (N = 2796) were serotyped for HSV1 and HSV2 and provided data on herpetic symptoms by questionnaire. Subjects reporting at least one episode of orobuccal ulcerative mucosal lesions were classified as clinically manifest orofacial herpes.
Results Lifetime prevalence of clinically manifest orofacial herpes was 38.3% (42.1% in women, 32.4% in men). Prevalence in subjects seropositive for HSV1 was 50.3%. This prevalence rate was independent of HSV2 serotype. Prevalence in subjects infected with HSV2 alone was similar to that in subjects seronegative for HSV.
Limitations Lack of case ascertainment limits precision of the data.
Conclusions Clinically manifest orofacial herpes was reported in one third of the sample, principally associated with HSV1 infection. HSV2 infection did not produce orofacial lesions nor influence clinical manifestations of HSV1 infection.