Conflict of Interest None declared.
Oxidative stress in acne vulgaris
Version of Record online: 23 NOV 2009
© 2009 The Authors. Journal compilation © 2009 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 24, Issue 7, pages 763–767, July 2010
How to Cite
Sarici, G., Cinar, S., Armutcu, F., Altınyazar, C., Koca, R. and Tekin, N. (2010), Oxidative stress in acne vulgaris. Journal of the European Academy of Dermatology and Venereology, 24: 763–767. doi: 10.1111/j.1468-3083.2009.03505.x
- Issue online: 7 JUN 2010
- Version of Record online: 23 NOV 2009
- Received: 24 February 2009; Accepted: 22 October 2009
- acne vulgaris;
- superoxide dismutase;
- xanthine oxidase
Background Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aimed to determine the effects of oxidative stress in acne vulgaris.
Materials and methods The study involved 32 patients with acne vulgaris in the patient group and 34 healthy adults in the control group. The parameters of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), xanthine oxidase (XO), nitric oxide (NO) and malondialdehyde (MDA) in the venous blood of patients were measured spectrophotometrically. The values were compared with those of the control group.
Results The serum levels of MDA and XO activity in the patients with acne vulgaris were significantly higher than those of the controls. A significantly lower SOD and CAT activity was found in the patient group than in the control group. Although the patient group had higher serum levels of NO than the control group, the difference was not statistically significant.
Conclusion These results suggest that oxidative damage may play a role in the pathogenesis of acne; therefore, significant alterations may occur in the antioxidant defence system.