Conflict of Interest The authors have no financial or other relationships that could lead to conflict of interest; all authors sate no conflict of interest.
C-reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy
Article first published online: 11 DEC 2009
© 2009 The Authors. Journal compilation © 2009 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 24, Issue 7, pages 789–796, July 2010
How to Cite
Coimbra, S., Oliveira, H., Reis, F., Belo, L., Rocha, S., Quintanilha, A., Figueiredo, A., Teixeira, F., Castro, E., Rocha-Pereira, P. and Santos-Silva, A. (2010), C-reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy. Journal of the European Academy of Dermatology and Venereology, 24: 789–796. doi: 10.1111/j.1468-3083.2009.03527.x
- Issue published online: 7 JUN 2010
- Article first published online: 11 DEC 2009
- Received: 22 July 2009; Accepted: 3 November 2009
- C-reactive protein;
- narrow-band ultraviolet light B;
- psolaren associated to ultraviolet light A;
- psoriasis vulgaris;
- topical therapy
Background Psoriasis vulgaris is a chronic recurrent inflammatory skin disease and psoriatic lesions have shown leucocyte infiltration.
Objectives We aimed to study C-reactive protein (CRP) and leucocyte activation markers/inhibitors as potential monitors of psoriasis vulgaris.
Methods A cross-sectional (n = 73) and a longitudinal study (before, at 3, 6 and 12 weeks of therapy; n = 47) was performed; 10 patients started topical treatment, 17 narrow-band ultraviolet light B (NBUVB) and 20 psolaren associated to UVA (PUVA); psoriasis severity was defined by Psoriasis Area and Severity Index (PASI).
Results Compared with control (n = 38), we found higher CRP levels, total leukocyte/neutrophil count, elastase, lactoferrin and α1-antitrypsin. Increasing PASI was linked to increasing CRP and a trend to higher elastase and lactoferrin, suggesting that worsening enhances inflammatory response with neutrophil activation. CRP correlated with PASI, total leucocytes, neutrophils, elastase, lactoferrin and α1-antitrypsin. NBUVB and PUVA presented similar effects.
Conclusion We propose CRP as a useful marker of psoriasis severity that could be used to monitor psoriasis and its treatment, and, together with PASI and elastase, could also be used as a global index of severity.