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C-reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy

Authors

  • S Coimbra,

    Corresponding author
    1. Faculdade de Farmácia, Serviço de Bioquímica, Universidade do Porto, Porto
    2. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto
    3. Centro de Investigação das Tecnologias da Saúde (CITS) – Instituto Politécnico da Saúde Norte, Gandra-Paredes
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  • H Oliveira,

    1. Serviço de Dermatologia, Hospitais da Universidade de Coimbra, Coimbra
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  • F Reis,

    1. Instituto de Farmacologia e Terapêutica Experimental, IBILI, Faculdade de Medicina, Universidade de Coimbra, Coimbra
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  • L Belo,

    1. Faculdade de Farmácia, Serviço de Bioquímica, Universidade do Porto, Porto
    2. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto
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  • S Rocha,

    1. Faculdade de Farmácia, Serviço de Bioquímica, Universidade do Porto, Porto
    2. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto
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  • A Quintanilha,

    1. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto
    2. Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto
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  • A Figueiredo,

    1. Serviço de Dermatologia, Hospitais da Universidade de Coimbra, Coimbra
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  • F Teixeira,

    1. Instituto de Farmacologia e Terapêutica Experimental, IBILI, Faculdade de Medicina, Universidade de Coimbra, Coimbra
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  • E Castro,

    1. Faculdade de Farmácia, Serviço de Bioquímica, Universidade do Porto, Porto
    2. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto
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  • P Rocha-Pereira,

    1. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto
    2. Centro de Investigação em Ciências da Saúde (CICS), Universidade da Beira Interior, Covilhã, Portugal
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  • A Santos-Silva

    1. Faculdade de Farmácia, Serviço de Bioquímica, Universidade do Porto, Porto
    2. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto
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  • Conflict of Interest
    The authors have no financial or other relationships that could lead to conflict of interest; all authors sate no conflict of interest.

Correspondence: S Coimbra. E-mail:ssn.coimbra@gmail.com

Abstract

Background  Psoriasis vulgaris is a chronic recurrent inflammatory skin disease and psoriatic lesions have shown leucocyte infiltration.

Objectives  We aimed to study C-reactive protein (CRP) and leucocyte activation markers/inhibitors as potential monitors of psoriasis vulgaris.

Methods  A cross-sectional (n = 73) and a longitudinal study (before, at 3, 6 and 12 weeks of therapy; n = 47) was performed; 10 patients started topical treatment, 17 narrow-band ultraviolet light B (NBUVB) and 20 psolaren associated to UVA (PUVA); psoriasis severity was defined by Psoriasis Area and Severity Index (PASI).

Results  Compared with control (n = 38), we found higher CRP levels, total leukocyte/neutrophil count, elastase, lactoferrin and α1-antitrypsin. Increasing PASI was linked to increasing CRP and a trend to higher elastase and lactoferrin, suggesting that worsening enhances inflammatory response with neutrophil activation. CRP correlated with PASI, total leucocytes, neutrophils, elastase, lactoferrin and α1-antitrypsin. NBUVB and PUVA presented similar effects.

Conclusion  We propose CRP as a useful marker of psoriasis severity that could be used to monitor psoriasis and its treatment, and, together with PASI and elastase, could also be used as a global index of severity.

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