Aesthetic effects of topical photodynamic therapy


  • Conflict of interest
    The authors certify that, to their knowledge, the work that is reported on in said manuscript has not received financial support from any pharmaceutical company or other commercial source except as described below. Neither the authors nor any first-degree relative have any special financial interest in the subject matter discussed in said manuscript. Dr Kohl and Prof. Landthaler declare no conflict of interest. Prof. Szeimies has received grants for participation in clinical trials from Abbott, Biofrontera AG, Galderma, 3M, meda Pharma, PhotoCure ASA, photonamic, Schering-Plough and Wyeth; has received honoraria for participation in advisory boards from Galderma, Intendis, and Peplin; has received honoraria as a speaker for Almirall-Hermal, Galderma, Intendis and photonamic. Dr Torezan has received grants for participation in clinical trials from Galderma; has received honoraria as a speaker for Galderma.

R-M Szeimies.


Topical photodynamic therapy has shown to be effective for the treatment of several aspects of skin ageing. Multiple studies have demonstrated improvement of fine wrinkles, mottled hyperpigmentation, tactile roughness and sallowness. These results are supported by immunohistochemical analysis that revealed both upregulation of collagen production and increased epidermal proliferation. Neocollagenesis as an indirect dermal effect of photodynamic therapy is stimulated through cytokine induction. This article reviews the available literature for photodynamic rejuvenation while discussing cosmetic effects, light sources, adverse effects and the mechanism of action.