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Individuals who are homozygous for the 2282del4 and R501X filaggrin null mutations do not always develop dermatitis and complete long-term remission is possible


  • Conflict of interests
    The authors have no conflict of interest to disclose.

  • Funding sources
    The Danish Board of Health, The Danish Environmental Protection Agency, The Copenhagen County Research Foundation, Aase and Einar Danielsens Foundation, The Velux Foundation, and The Danish Scientific Research Council supported the general population study from Glostrup Hospital.

  • Prior presentations: The content has not been published previously and is not otherwise submitted for publication.

J.P. Thyssen.


Background  About 8–10% of the general population in Europe carry a null mutation in the filaggrin gene which is associated with early onset of atopic dermatitis as well as persistence into adulthood. No studies have investigated whether individuals with the homozygous filaggrin null genotype always develop dermatitis.

Objectives  The aim of this study was to describe the natural history of individuals with no filaggrin expression.

Materials  Three study populations were included: (i) a random sample of 3335 subjects aged 18–69 years from the general population in Copenhagen who underwent general health examination; (ii) a total of 499 patients seen in our dermatitis clinic since 2009 and who were filaggrin genotyped as a part of the routine diagnostic work up; and (iii) a prospective, longitudinal, birth cohort study of 411 children born to mothers with a history of asthma. Filaggrin genotyping was performed for the 2282del4 and R501X mutations.

Results  Filaggrin homozygous/compound heterozygous individuals accounted for 0.3% of adults, 3% of dermatitis patients and 0.7% of children. Respectively, one of nine adults and one of three children never experienced dermatitis until now. All hospital patients had atopic dermatitis with onset during (early) childhood. Year-long complete remission was observed in half of patients.

Conclusions  The natural history of individuals with the filaggrin null genotype is fairly good in the sense that they may not develop dermatitis at all, and if they do, they may experience complete remission.