Conflicts of interest None declared.
Influence of severity of the cutaneous manifestations and age on the prevalence of several cardiovascular risk factors in patients with psoriasis
Version of Record online: 4 MAY 2011
© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 26, Issue 3, pages 348–353, March 2012
How to Cite
Rosa, D.J.F., Machado, R.F., Matias, F.A.T., Cedrim, S.D., Noronha, F.L., Gaburri, D. and Gamonal, A. (2012), Influence of severity of the cutaneous manifestations and age on the prevalence of several cardiovascular risk factors in patients with psoriasis. Journal of the European Academy of Dermatology and Venereology, 26: 348–353. doi: 10.1111/j.1468-3083.2011.04076.x
Funding sources None.
- Issue online: 17 FEB 2012
- Version of Record online: 4 MAY 2011
- Received: 19 November 2010; Accepted: 18 March 2011
Introduction Psoriasis is a disease with proinflammatory state that has been associated with an increased risk of cardiovascular disease.
Method This is a cross-sectional, observational study, with analysis of 98 patients being treated for psoriasis. Several variables were analysed: gender, age, weight, height, Psoriasis Area and Severity Index (PASI), blood pressure, blood glucose, blood lipids, obesity, metabolic syndrome (MS) and Framingham score.
Results Ninety-eight patients were analysed (51 men; 52.0%). Age ranged from 12 years to 98 years. About 67% of the patients had dyslipidaemia, 14.3% had type 2 diabetes mellitus and 59.2% had systemic arterial hypertension. Forty-four percentage of patients had the MS and 27.6% had a body mass index >30 kg/m2. The Psoriasis Area and Severiy Index were equal or over 10 in 27 patients, 18 of whom had dyslipidaemia (P = 0.929) and 14 of whom had the MS (P = 0.327). Seventy-four patients were over the age of 40 years and, of these, 56 had dyslipidaemia (P = 0.002) and 41 had the MS (P < 0.001). For 89 patients, whose cardiovascular risk was calculated according to the Framingham criteria, 71.4% at high or moderate risk had a PASI below 10 (P = 0.945) and 100% at high or moderate risk were over the age of 40 years (P = 0.001).
Conclusion There was strong evidence that psoriasis patients have an increased cardiovascular risk, chiefly those over the age of 40 years, probably because of the chronic inflammatory state. It seems that the severity of the cutaneous manifestations was not associated with a higher risk in these patients.