Funding sources This study was carried out with the financial support of Vermont Italia Srl, Italy.
Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)
Article first published online: 14 SEP 2011
© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 26, Issue 11, pages 1449–1453, November 2012
How to Cite
Pedrelli, V.F., Lauriola, M.M. and Pigatto, P.D. (2012), Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols). Journal of the European Academy of Dermatology and Venereology, 26: 1449–1453. doi: 10.1111/j.1468-3083.2011.04219.x
Conflict of interest The Authors declare that they have not other potential conflict of interest (personal relationship). All the authors have participated sufficiently to take public responsibility for appropriate portions of the work.
- Issue published online: 16 OCT 2012
- Article first published online: 14 SEP 2011
- Received: 13 February 2011; Accepted: 17 August 2011
Background Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols. Moreover, vitamin A is well-known in dermatology for its actions, including the ultraviolet radiation absorbing property.
Objectives In view of experimental evidence for the photoprotective properties of these antioxidants, we evaluated in 30 patients with photosensitivity, the prophylactic efficacy of a new topical agent, containing tocopherols 10% and tocotrienols 0.3%, compared with retinol, simple vehicle and untreated areas.
Methods After determination of the minimal UVB erythema dose (MED), two areas of 2 × 2 cm were selected on the buttocks of each subject, one of which was treated with the antioxidant formulation whereas the other field did not undergo any treatment. Therefore, both areas were irradiated with a twofold MED. As further controls, other two similar areas, selected on the forearm of 15 patients, were photo-irradiated similarly, 30 min after application of the simple vehicle to a field and of vitamin A in the same vehicle to the other. Reactions (erythema/oedema/itch/vesciculation) assessment was carried out assigning scores indicative of their intensity; then, mean values +DS of scores were calculated.
Results The pre-treatment with the vitamin E formulation highly protects against photosensitivity, and all reactions to irradiation were significantly lower in the areas treated with the topical vitamin E formulation compared to those treated with the simple vehicle or vitamin A.
Conclusions The use of a new topical formulation containing significant concentrations of tocotrienols and tocopherols represents a promising strategy to reduce the photo-induced skin damage.