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% NIL% reduction in non-inflamed lesion count from baseline
% IL% reduction in inflamed lesions count from baseline
%TL% reduction in total lesion count from baseline
AAssessor
AE’sAdverse event/s
BBlinding
BIDBis in die/twice daily
BLDBaseline differences between groups
BPOBenzoyl peroxide
CCClosed comedones
COComedones
COAConclusion of author
concConcentration
dDay/s
DDuration (weeks)
EEnroller
QODQuoque alternis die/every other day
ELEvidence level/Level of evidence
ERExtended-release
GITGastrointestinal disorder
HClHydrochloride
ILInflamed lesions
IInvestigator
ITTIntention to treat analysis
LTFLost to follow up
mmonth/s
NNumber of individuals randomised
n.d.Not described
NILNon- inflamed lesions
NONodules
NSNot significant
OOpen/not blinded
OCOpen comedones
QDQuaque die/once per day
oogOut of graph/(efficacy) data out of graph
PPatient
PAPapules
PhpPhosphate
poPer os/by mouth/orally
PUPustules
QIDQuarter die sumendus/four times a day
RRandomization
rel.related
SSeverity: 1 = mild, 2 = moderate, 3 = severe
SSStatistically significant (P ≤ 0.05)
TAcne type
TIDTer die sumendus/three times a day
TMGTretinoin microsphere gel
top.Topical
v/vs.Versus
VASVisual analogue scale
wWeek/s
w/owith/without
No detailed information available/no SS differences between arms
+Randomized

Columns:

Other Outcomes / statistics: if no information about lesion count is available another measurement was documented, only SS differences between the arms are written down (no SS differences concerning change from baseline to date of evaluation are noted)

‘-’ means: there are no SS differences between arms

D: if duration of study and week of efficacy evaluation not equal than x/ y (where x means weeks of treatment and y means time point of efficacy evaluation)

Drop outs: preliminary number of drop outs due to AEs, as stated

Reason for exclusion:

No efficacy data:

  • [RIGHTWARDS ARROW]
     no numbers for lesion count or comparable outcome measurement

Intervention not included:

  • [RIGHTWARDS ARROW]
     not included intervention
  • [RIGHTWARDS ARROW]
     if the study has a non included comparator the other arm will be excluded as well

No prospective study:

  • [RIGHTWARDS ARROW]
     not a prospective study