Conflict of interest None.
Report of 457 sporotrichosis cases from Jilin province, northeast China, a serious endemic region
Article first published online: 17 DEC 2011
© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 3, pages 313–318, March 2013
How to Cite
Song, Y., Li, S.-S., Zhong, S.-X., Liu, Y.-Y., Yao, L. and Huo, S.-S. (2013), Report of 457 sporotrichosis cases from Jilin province, northeast China, a serious endemic region. Journal of the European Academy of Dermatology and Venereology, 27: 313–318. doi: 10.1111/j.1468-3083.2011.04389.x
Funding sources None.
- Issue published online: 18 FEB 2013
- Article first published online: 17 DEC 2011
- Received: 3 May 2011; Accepted: 8 November 2011
Background Most reported sporotrichosis cases came from South American countries, the USA, India and Japan. This mycosis is also endemic in Northeast China. However, the situation is not clear for international researchers due to lack of large series reported in English.
Objectives To report and analyse 457 sporotrichosis cases.
Methods Retrospective study of 457 cases of sporotrichosis diagnosed by fungal culture at the First Hospital of Jilin University from 1 January 2007 to 31 December 2009.
Results In this series, the male: female ratio was 1:1.42. Mean age was 41.2 years. Cases from age group 51–60 years accounted for most of the cases (22.54%). A total of 434 patients lived in rural areas (94.97%). The onset of symptoms in 67.61% cases happened in cold seasons (winter and spring). History of trauma presented in 133 cases (29.1%). The mean duration of the symptoms before the presentation was 6.41 months. A total of 190 (41.58%) showed lymphocutaneous form, 252 patients (55.14%) showed fixed form, 8 patients (1.75%) showed disseminated cutaneous sporotrichosis and the clinical form of 7 patients (1.53%) could not be defined. Extremities and nodules were the most frequently involved sites and founded manifestation. Main histopathology findings were suppurative granuloma, tuberculoid granuloma and mixed inflammatory granuloma. A total of 75 cases (19.74%) had fungal elements revealed by Periodic Acid-Schiff staining. Patients responded well to potassium iodide (KI), itraconazole, terbinafine and combinations of these agents with a mean course of 2.17 months to resolve.
Conclusion As the first report of a large series of sporotrichosis cases from China to be published in English literature, our study indicated a serious sporotrichosis endemic situation in Jilin province, Northeast China, with epidemiological and clinical characteristics similar to those of previous Chinese reports, but different from those in other countries. KI, itraconazole and terbinafine are effective for the treatment.