Few case series have shown efficacy of rituximab in resistant cases of pemphigus. There are individual case reports of use of rituximab in childhood pemphigus.
Efficacy and safety of rituximab treatment in Indian pemphigus patients
Article first published online: 17 DEC 2011
© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 1, pages e17–e23, January 2013
How to Cite
Kanwar, A.J., Tsuruta, D., Vinay, K., Koga, H., Ishii, N., Dainichi, T. and Hashimoto, T. (2013), Efficacy and safety of rituximab treatment in Indian pemphigus patients. Journal of the European Academy of Dermatology and Venereology, 27: e17–e23. doi: 10.1111/j.1468-3083.2011.04391.x
We have shown the efficacy of rituximab in the Indian pemphigus patients, for the first time. Clinical response showed good correlation with fall in anti-Dsg1 antibody indices, whereas there was only a partial reduction in anti-Dsg3 indices. Childhood pemphigus also responded to rituximab therapy.
Funding source This study was supported by Grants-in-Aid for Scientific Research and Strategic Research Basis Formation Supporting Project from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by Health and Labour Sciences Research Grants and grants for Research on Measures for Intractable Diseases from the Ministry of Health, Labour and Welfare of Japan. The study was also supported by grants from the Uehara Memorial Foundation, Nakatomi Foundation, Kaibara Morikazu Medical Science Promotion Foundation, Japan Lydia O’Leary Memorial Foundation, Cosmetology Research Foundation, Japanese Dermatological Association (Shiseido Award), Fukuoka Foundation for Sound Health, and Galderma K.K. (Galderma Award).
Conflict of interest None.
- Issue published online: 18 DEC 2012
- Article first published online: 17 DEC 2011
- Received: 31 August 2011; Accepted: 21 November 2011
- 13Treatment of severe pemphigus with a combination of immunoadsorption, rituximab, pulsed dexamethasone, and azathioprine/mycophenolate mofetil: a pilot study of 23 patients. Br J Dermatol 2011; Forthcoming Sep12. doi: 10.1111/j.1365-2133.2011.10585.x., , et al.