Conflict of interest The authors declare no conflict of interest.
Lack of association between filaggrin gene mutations and onset of psoriasis in childhood
Article first published online: 20 DEC 2011
© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 1, pages e124–e127, January 2013
How to Cite
Winge, M.C.G., Suneson, J., Lysell, J., Nikamo, P., Liedén, A., Nordenskjöld, M., Wahlgren, C.F., Bradley, M. and Ståhle, M. (2013), Lack of association between filaggrin gene mutations and onset of psoriasis in childhood. Journal of the European Academy of Dermatology and Venereology, 27: e124–e127. doi: 10.1111/j.1468-3083.2011.04403.x
Funding sources The study was performed with grants from Welander and Finsen foundations, Psoriasisforbundet, the Centre for Allergy Research (CFA) and through the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- Issue published online: 18 DEC 2012
- Article first published online: 20 DEC 2011
- Received: 23 September 2011; Accepted: 25 November 2011
Background Atopic dermatitis (AD; OMIM#603165) and psoriasis (OMIM#177900) are two common inflammatory skin disorders. Both are genetically complex, multifactorial and do not follow a Mendelian pattern of inheritance. Both diseases share several genetic susceptibility loci such as the epidermal differentiation complex (EDC) on chromosome 1q21. Within the EDC, mutations in the filaggrin (FLG) gene are strongly associated with AD whereas no association has been replicated with psoriasis. However, reduced levels of filaggrin have been reported in psoriatic skin. Further, filaggrin deficiency was shown to be a modifying factor for the phenotype in another epidermal skin disorder, X-linked recessive ichthyosis. Altogether, this raises the question if FLG mutations may modify the disease course in other epidermal skin diseases such as psoriasis. Psoriasis is a highly heterogeneous disease and so far genetic studies have not taken the distinct sub-phenotype childhood onset into account.
Objective To determine if FLG mutations modify the onset of psoriasis.
Materials and methods A total of 241 children with onset of psoriasis below 15 years of age and 314 healthy controls were identified at the Dermatology clinic, Karolinska University Hospital and diagnosed by the same dermatologist (JL). Blood samples were taken and medical history was recorded. FLG was genotyped in all patients and controls using allelic discrimination (n = 555) and sequencing (n = 20).
Results and conclusions No association between FLG mutations and early onset of psoriasis was demonstrated (P = 0.57) and no novel mutations were detected, indicating that FLG loss-of-function variants do not have a strong effect on the onset of psoriasis in childhood.