Conflict of interest The authors state no conflict of interest.
Frequency of non-histologically diagnosed basal cell carcinomas in daily Dutch practice
Article first published online: 3 JAN 2012
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 7, pages 907–911, July 2013
How to Cite
Flohil, S.C., van Tiel, S., Koljenović, S., Jaanen-van der Sanden, G., Overbeek, L.I.H., de Vries, E. and Nijsten, T. (2013), Frequency of non-histologically diagnosed basal cell carcinomas in daily Dutch practice. Journal of the European Academy of Dermatology and Venereology, 27: 907–911. doi: 10.1111/j.1468-3083.2011.04407.x
Funding sources This study was funded by the Netherlands organisation for health research and development, ZonMw (project number 152001013).
- Issue published online: 13 JUN 2013
- Article first published online: 3 JAN 2012
- Received: 26 August 2011; Accepted: 30 November 2011
Background Population-based basal cell carcinoma (BCC) incidences are based on cancer registry data; however, these only include histologically diagnosed tumours.
Objectives First, to investigate the number of subsequent non-histologically diagnosed BCC(s) in patients with a first histologically diagnosed BCC in 2004. Secondly, to observe differences in tumour characteristics between subsequent histologically and subsequent non-histologically diagnosed BCC(s).
Methods All patients, from four hospitals located in the serving area of the Eindhoven Cancer Registry, with a first histologically diagnosed BCC in 2004 (n = 1290) were selected. A linkage was made with PALGA, the nationwide network and registry of histo- and cytopathology, to obtain pathology reports of subsequent histologically diagnosed BCC(s) up to 1 November 2010. Patient records were extracted from the participating dermatology departments and reviewed up to 1 November 2010 to identify non-histologically diagnosed BCC(s).
Results Overall, 33.2% of the 1089 followed up patients developed subsequent histologically and/or non-histologically diagnosed BCCs. In total, 1974 BCCs were observed of which 1833 were histologically and 141 were non-histologically diagnosed BCCs. The distribution of tumour site and subtype differed significantly between subsequent histologically and subsequent non-histologically diagnosed BCCs.
Conclusions The total burden of BCC is underestimated by the absence of data on the occurrence of non-histologically diagnosed BCCs in daily dermatological practice. It is pivotal for Dutch healthcare policy makers to acknowledge this to make accurate BCC-related cost estimates.