Conflict of interest None declared.
Prurigo as a symptom of atopic and non-atopic diseases: aetiological survey in a consecutive cohort of 108 patients
Article first published online: 25 FEB 2012
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 5, pages 550–557, May 2013
How to Cite
Iking, A., Grundmann, S., Chatzigeorgakidis, E., Phan, N.Q., Klein, D. and Ständer, S. (2013), Prurigo as a symptom of atopic and non-atopic diseases: aetiological survey in a consecutive cohort of 108 patients. Journal of the European Academy of Dermatology and Venereology, 27: 550–557. doi: 10.1111/j.1468-3083.2012.04481.x
Funding sources None declared.
- Issue published online: 10 APR 2013
- Article first published online: 25 FEB 2012
- Received: 21 October 2011; Accepted: 27 January 2012
Background Prurigo nodularis Hyde (PN) is a highly pruritic condition due to a vicious circle of repeated itching and scratching. There are no representative clinical studies investigating comorbidities in a large collective of PN patients.
Objective This pilot study aimed to investigate the exact distribution of the coexisting diseases in a large representative consecutive cohort of PN patients.
Methods A total of 108 PN patients (36.1% male; mean age of 61.5 ± 16.7 years) were enrolled in the study.
Results In 87.0% of patients, diseases underlying PN could be established (18.5% skin disease, 7.4% systemic origin, 1.8% neurological diseases, 59.3% mixed origin). Due to several possible causative co-factors, the majority of patients were classified in the group of mixed origin (59.3%). In 53.1% of these patients, at least one dermatological factor was involved in the induction of PN. Interestingly, nearly half (46.3%) of all PN patients had either an atopic predisposition or atopic dermatitis as a single cause of PN (18.5%) or as one co-factor of PN of mixed origin (27.8%). Considering the different underlying diseases, there was no significant age or gender difference.
Conclusion PN does not seem to represent a characteristic symptom of one disease only. Multiple pruritogenic diseases are linked to evolution and improvement of PN upon treatment. Atopic predisposition is a major factor in nearly half of PN patients. The large collective of the present study helped detect a broad range of underlying diseases and thus to provide recommendations for rational diagnostics.