Conflict of interest None declared.
Effects of 420-nm intense pulsed light in an acne animal model
Article first published online: 25 FEB 2012
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 9, pages 1168–1171, September 2013
How to Cite
Fan, X., Xing, Y.-Z., Liu, L.-H., Liu, C., Wang, D.-D., Yang, R.-Y. and Lapidoth, M. (2013), Effects of 420-nm intense pulsed light in an acne animal model. Journal of the European Academy of Dermatology and Venereology, 27: 1168–1171. doi: 10.1111/j.1468-3083.2012.04487.x
Funding sources None declared.
- Issue published online: 28 JUL 2013
- Article first published online: 25 FEB 2012
- Received: 16 August 2011; Accepted: 31 January 2012
Background Blue light in the 400–420 nm range has been shown to reduce the levels of Propionibacterium acnes (P. acnes) in the skin. P. acnes has been postulated to be a critical trigger for inflammatory acne. Thus, treatment with 420 nm-intense pulsed light should reduce inflammatory activity in acne.
Aim To evaluate the clinical and histological effects of 420 nm-intense pulsed light treatment on acne in animal model.
Method Inflammation acne animal model was constructed by intradermal injection of P. acnes of rat auricular. Levels of tumour necrosis factor alpha (TNF-α) and matrix metalloproteinase 2 (MMP-2), markers of inflammation implicated in acne, were assessed in treated and untreated animals by immunohistochemistry and quantitative polymerase chain reaction (PCR).
Result Treatment with 420 nm intense pulsed light led to marked improvement after 6 biweekly treatments. Immunohistochemistry and PCR showed that TNF-α and MMP-2 levels correlated with the extent of acneiform activity and were reduced by treatment with 420 nm light.
Conclusion A 420-nm intense pulsed light may exert its beneficial effects on inflammatory acne by reducing the levels of P. acnes and secondarily reducing inflammation induced by the bacteria.