Clinicopathological study of invasive extramammary Paget’s disease: subgroup comparison according to invasion depth


  • Conflict of interest
    None declared.

  • Funding sources
    This works was not supported by any funding.

T. Shiomi.


Background  Extramammary Paget’s disease (EMPD) is a distinct form of malignant skin neoplasm. Invasive EMPD is relatively rare and its detailed histopathological features have not been investigated to date.

Methods  Surgical specimens were obtained from 51 patients with primary invasive EMPD. Clinical data including lymph node status were retrieved from the patients’ medical records. Cases were divided into subgroups according to invasion depth: dermal invasion ≤1 mm (minimal invasion) and dermal invasion >1 mm in depth. Histological patterns (nodular/glandular pattern or micronodular pattern), lymphatic/venous invasion, mitosis and lymph node status were compared between the two groups.

Results  The invasive EMPDs included 26 cases (51.0%) with dermal invasion ≤1 mm (minimal invasion) and 25 cases (49.0%) with dermal invasion >1 mm in depth. Lymph node metastasis was detected in 2/26 (7.7%) patients with minimally invasive EMPD. Nodular/glandular pattern (72.0%), lymphatic/venous invasion (52.0%), mitosis (88.0%) and nodal metastasis (88.0%) were all significantly more frequent in cases with dermal invasion >1 mm, compared to EMPDs with dermal invasion ≤1 mm (minimal invasion) (< 0.001).

Conclusion  These results suggest that invasive EMPD can be divided according to invasion depth, with a cut-off depth of 1 mm. This might represent the basis for a useful, EMPD-specific staging system.