Conflict of interest The authors do not declare any conflicts of interest.
HLA alleles in Brazilian patients with fissured tongue
Article first published online: 28 MAR 2012
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 2, pages e166–e170, February 2013
How to Cite
Gonzaga, H.F.S., Marcos, E.V.C., Santana, F.C.S., Jorge, M.A. and Tomimori, J. (2013), HLA alleles in Brazilian patients with fissured tongue. Journal of the European Academy of Dermatology and Venereology, 27: e166–e170. doi: 10.1111/j.1468-3083.2012.04537.x
- Issue published online: 22 JAN 2013
- Article first published online: 28 MAR 2012
- Received: 21 September 2011; Accepted: 5 March 2012
Background Fissured tongue (FT) is a clinical condition manifested by numerous little furrows on the tongue’s surface. Previously, the authors observed an association with HLA-C×06 in psoriasis (PS) and benign migratory glossitis (BMG); however, HLA-C was not surveyed in FT.
Objective This study investigated the association between HLA alleles and FT.
Methods Thirty-three FT bearers were studied, after evaluation of criteria for inclusion. These patients did not present PS, BMG or any other conditions associated with FT. The control group (CG) was composed of 561 individuals with HLA-A, 560 individuals with HLA-B, 168 individuals with HLA-C, 564 individuals with HLA-DRB1 and 390 individuals with HLA-DQB1. Samples from these individuals were processed to extract DNA. The HLA classes I and II were determined using the reverse line blot technique. The frequencies of HLA antigens found in patients were compared with the CG using Fisher’s exact test.
Results The comparison of the frequencies of HLA antigens found in the patient groups and in CG revealed no association with any of the alleles studied, except for HLA-A*01, which exhibited a decreased frequency in patient groups. HLA-C*06 was detected in 7.57% of FT patients and 10.42% of the CG (not significant).
Conclusion The lack of association of FT with HLA-C*06 reinforces the proposal that this disease does not have a common genetic factor in the triad of BMG, FT and PS.