ORIGINAL ARTICLE

Clinical, dermoscopic and reflectance confocal microscopy features of sebaceous neoplasms in Muir–Torre syndrome

  1. E. Moscarella1,
  2. G. Argenziano2,*,
  3. C. Longo2,
  4. C. Cota3,
  5. M. Ardigò4,
  6. V. Stigliano5,
  7. L.S. Mete5,
  8. P. Donati3,
  9. S. Piana6,
  10. V. Silipo1,
  11. C. Catricalà1,
  12. G. Albertini2,
  13. I. Zalaudek7

Article first published online: 4 APR 2012

DOI: 10.1111/j.1468-3083.2012.04539.x

Issue

Journal of the European Academy of Dermatology and Venereology

Journal of the European Academy of Dermatology and Venereology

Volume 27, Issue 6, pages 699–705, June 2013

Additional Information

How to Cite

Moscarella, E., Argenziano, G., Longo, C., Cota, C., Ardigò, M., Stigliano, V., Mete, L.S., Donati, P., Piana, S., Silipo, V., Catricalà, C., Albertini, G. and Zalaudek, I. (2013), Clinical, dermoscopic and reflectance confocal microscopy features of sebaceous neoplasms in Muir–Torre syndrome. Journal of the European Academy of Dermatology and Venereology, 27: 699–705. doi: 10.1111/j.1468-3083.2012.04539.x

Author Information

  1. 1

    Department of Oncologic Dermatology, San Gallicano Dermatologic Institute, Rome, Italy

  2. 2

    Dermatology Unit, Medical Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

  3. 3

    Department of Dermatopathology, San Gallicano Dermatologic Institute, Rome, Italy

  4. 4

    Department of Dermatology, San Gallicano Dermatologic Institute, Rome, Italy

  5. 5

    Department of Gastroenterology, Regina Elena Cancer Institute, Rome, Italy

  6. 6

    Department of Pathology, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

  7. 7

    Department of Dermatology, Medical University of Graz; Graz, Austria

* G. Argenziano. E-mail:g.argenziano@gmail.com

  1. Conflict of interest None.

  2. Funding source None.

  3. Funding support Dr Elvira Moscarella is currently supported by the Funding support the Italian Ministry of Health Ricerca Finalizzata 2007 (C. Catricalà) and ISS-ACC (C. Catricalà).

Publication History

  1. Issue published online: 8 MAY 2013
  2. Article first published online: 4 APR 2012
  3. Received: 15 December 2011; Accepted: 7 March 2012

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Abstract

Background  Muir–Torre syndrome (MTS) is an autosomal-dominant disorder characterized by the association of sebaceous tumors or keratoacanthomas with an early onset visceral cancer in the spectrum of Lynch syndrome.

Observations  A total of 20 sebaceous tumors including 18 sebaceous adenoma and two sebaceomas of six patients with MTS were analysed. Two main clinico-dermoscopic features were observed: (1) clinically pink to white papules/nodules with a central crater, dermoscopically characterized by radially arranged, elongated crown vessels surrounding opaque structureless yellow areas at times covered by blood crusts (n = 13) and (2), clinically pink to yellow papules/nodules without a central crater, dermoscopically exhibiting a few, loosely arranged yellow comedo-like globules and branching arborizing vessels (n = 7). Confocal microscopy was available in three sebaceous adenomas and revealed a good histopathologic correlation; sebaceous lobules were composed by clusters of ovoid cells with dark nuclei and bright, highly refractile glistening cytoplasm. They were delimited by a rim of epithelial cells, corresponding to basaloid cells.

Conclusions  A better characterization of clinical, dermoscopic and confocal microscopy features of sebaceous tumors may improve their recognition and consequently, aid to rise the suspect for MTS.

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