Conflict of interests The authors declare that they have no conflicts of interest.
Morphology of basal cell carcinoma in high definition optical coherence tomography: en-face and slice imaging mode, and comparison with histology
Article first published online: 28 APR 2012
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 1, pages e97–e104, January 2013
How to Cite
Maier, T., Braun-Falco, M., Hinz, T., Schmid-Wendtner, M.H., Ruzicka, T. and Berking, C. (2013), Morphology of basal cell carcinoma in high definition optical coherence tomography: en-face and slice imaging mode, and comparison with histology. Journal of the European Academy of Dermatology and Venereology, 27: e97–e104. doi: 10.1111/j.1468-3083.2012.04551.x
Funding sources This work was supported by the Curd-Bohnewand-Fonds of the University of Munich (to TM), by the Matthias Lackas Foundation and the Dr. Helmut Legerlotz Foundation (to CB).
- Issue published online: 18 DEC 2012
- Article first published online: 28 APR 2012
- Received: 27 January 2012; Accepted: 27 March 2012
Background Optical coherence tomography (OCT) allows real-time, in vivo examination of basal cell carcinoma (BCC). A new high definition OCT with high lateral and axial resolution in a horizontal (en-face) and vertical (slice) imaging mode offers additional information in the diagnosis of BCC and may potentially replace invasive diagnostic biopsies.
Objectives To define the characteristic morphologic features of BCC by using high definition optical coherence tomography (HD-OCT) compared to conventional histology.
Methods A total of 22 BCCs were examined preoperatively by HD-OCT in the en-face and slice imaging mode and characteristic features were evaluated in comparison to the histopathological findings.
Results The following features were found in the en-face mode of HD-OCT: lobulated nodules (20/22), peripheral rimming (17/22), epidermal disarray (21/22), dilated vessels (11/22) and variably refractile stroma (19/22). In the slice imaging mode the following characteristics were found: grey/dark oval structures (18/22), peripheral rimming (13/22), destruction of layering (22/22), dilated vessels (7/22) and peritumoural bright stroma (11/22). In the en-face mode the lobulated structure of the BCC was more distinct than in the slice mode compared to histology.
Conclusion HD-OCT with a horizontal and vertical imaging mode offers additional information in the diagnosis of BCC compared to conventional OCT imaging and enhances the feasibility of non-invasive diagnostics of BCC.