Olfa Abida and Bochra Gargouri equally contributed to this work.
Biomarkers of oxidative stress in epidermis of Tunisian pemphigus foliaceus patients
Article first published online: 28 JUN 2012
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 3, pages e271–e275, March 2013
How to Cite
Abida, O., Gargouri, B., Ben Mansour, R., Mseddi-Djemal, M., Masmoudi, A., Ben Ayed, M., Abdelmoula, M., Turki, H., Lassoued, S. and Masmoudi, H. (2013), Biomarkers of oxidative stress in epidermis of Tunisian pemphigus foliaceus patients. Journal of the European Academy of Dermatology and Venereology, 27: e271–e275. doi: 10.1111/j.1468-3083.2012.04626.x
Conflict of interest None declared.
- Issue published online: 18 FEB 2013
- Article first published online: 28 JUN 2012
- Received: 3 April 2012; Accepted: 30 May 2012
Background Reactive oxygen species play a key role in the development of many dermatological disorders.
Objective The purpose of this study is to examine the lipid peroxidation, protein oxidation and antioxidative profile in Tunisian pemphigus foliaceus (PF) patients.
Methods Malondialdehyde (MDA), conjugated dienes (CD), protein thiol levels, catalase (CAT) and superoxide dismutase (SOD) activities were evaluated in skin biopsies of 13 patients compared to biopsies of 7 healthy controls.
Results Oxidative stress was confirmed in these three types of patient biopsies as compared to controls. Thus, MDA, CD levels and catalase CAT and SOD activities were significantly increased in lesional, perilesional and normal biopsies of PF patients than in those of control subjects. Protein oxidative was confirmed by lower levels of protein thiols in lesional, perilesional and normal biopsies than in control’s biopsies. Otherwise, in patients, a significant rise of these biomarkers was observed in lesional and perilesional biopsies compared with normal biopsies.
Conclusion This study shows that oxidative stress could be involved in the pathogenesis of PF by the spread of skin lesions and/or by the increase in auto-antibodies’ reactivity.