Conflict of Interest None
Macrophage migration inhibitory factor gene polymorphism is not associated with pemphigus vulgaris in Iranian patients
Article first published online: 22 AUG 2012
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 9, pages 1127–1131, September 2013
How to Cite
Saeedi, M., Amoli, M.M., Robati, R.M., Sayahpour, F., Namazi, N. and Toossi, P. (2013), Macrophage migration inhibitory factor gene polymorphism is not associated with pemphigus vulgaris in Iranian patients. Journal of the European Academy of Dermatology and Venereology, 27: 1127–1131. doi: 10.1111/j.1468-3083.2012.04676.x
[Correction added on 28 August 2012, after first online publication: ‘Microphage’ in the title was changed to ‘Macrophage’.]
- Issue published online: 28 JUL 2013
- Article first published online: 22 AUG 2012
- Received: 13 May 2012; Accepted: 11 July 2012
Background Promoter polymorphisms of the macrophage migration inhibitory factor gene are associated with increased production of macrophage migration inhibitory factor. Elevated levels of macrophage migration inhibitory factor have been observed in the sera of patients with pemphigus vulgaris. More than this, macrophage migration inhibitory factor promoter gene polymorphism has been found to confer increased risk of susceptibility to chronic inflammatory diseases.
Objective We investigated whether there is an association between promoter polymorphism of the macrophage migration inhibitory factor gene and pemphigus vulgaris.
Methods One hundred and six patients with pemphigus vulgaris, and a control panel of one hundred healthy volunteers were genotyped for a single nucleotide polymorphism identified in the 5′-flanking region at the position −173 of the gene, using polymerase chain reaction–restriction fragment length analysis.
Results We found a notably high prevalence of C/C genotype in our nation but no significant difference was observed between patients and controls.
Conclusion The result of this study using a large and well documented trial of patients showed that macrophage migration inhibitory factor −173G-C polymorphism is not associated with pemphigus vulgaris; but as the role of macrophage migration inhibitory factor in the inflammatory process has not been delineated in detail and the prevalence of C/C genotype is notably higher in our nation, this finding merits more consideration.