These authors contributed equally to this work.
Gene–gene interactions in IL23/Th17 pathway contribute to psoriasis susceptibility in Chinese Han population
Article first published online: 22 AUG 2012
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 9, pages 1156–1162, September 2013
How to Cite
Wang, W.-J., Yin, X.-Y., Zuo, X.-B., Cheng, H., Du, W.-D., Zhang, F.-Y., Yang, S. and Zhang, X.-J. (2013), Gene–gene interactions in IL23/Th17 pathway contribute to psoriasis susceptibility in Chinese Han population. Journal of the European Academy of Dermatology and Venereology, 27: 1156–1162. doi: 10.1111/j.1468-3083.2012.04683.x
Conflict of Interest The authors declare no conflict of interests.
Funding Sources This study was supported by Youth Project (81000692) and Normal Project (30971644) of National Natural Science Foundation of China, Anhui High Education Project (KJ2010B402), Anhui Province Natural Science Foundation (1208085QH145) and Chinese Society of Dermatology LEO Foundation.
- Issue published online: 28 JUL 2013
- Article first published online: 22 AUG 2012
- Received: 27 March 2012; Accepted: 19 July 2012.
Background Psoriasis is a common chronic inflammatory skin disease. IL23/Th17 is a newly confirmed pathway in psoriasis.
Objective To investigate the gene–gene interactions in IL23/Th17 pathway underlying psoriasis.
Methods A total of 299 single-nucleotide polymorphisms from 11 genes in IL23/Th17 pathway were genotyped on 1139 patients with psoriasis and 1694 controls. Multifactor dimensionality reduction and logistic regression algorithms were applied to explore the gene–gene interactions.
Results We found that there were a three-way interaction among IL21, CCR4 and TNF(χ2 = 5.02(1), P = 0.025) and three pair-wise gene–gene interactions between IL12RB1 and CCR4(χ2 = 11.66(4), P = 0.0201), IL22 and CCR4 (χ2 = 11.97(4), P = 0.0176), IL12RB1 and IL6 (χ2 = 7.31(1), P = 0.0069) in psoriasis.
Conclusions Our results might be helpful for explaining the missing heritability of the psoriasis due to epistasis and provide a deep insight into the important role of the IL23/Th17 pathway in the pathogenesis of psoriasis.