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Gene–gene interactions in IL23/Th17 pathway contribute to psoriasis susceptibility in Chinese Han population

Authors

  • W.-J. Wang,

    1. Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
    2. Key Lab of Dermatology, Ministry of Education, Hefei, Anhui, China
    3. State Key Lab Incubation of Dermatology, Ministry of Science and Technology, Hefei, Anhui, China
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    • These authors contributed equally to this work.

  • X.-Y. Yin,

    Corresponding author
    1. Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
    2. Key Lab of Dermatology, Ministry of Education, Hefei, Anhui, China
    3. State Key Lab Incubation of Dermatology, Ministry of Science and Technology, Hefei, Anhui, China
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    • These authors contributed equally to this work.

  • X.-B. Zuo,

    1. Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
    2. Key Lab of Dermatology, Ministry of Education, Hefei, Anhui, China
    3. State Key Lab Incubation of Dermatology, Ministry of Science and Technology, Hefei, Anhui, China
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  • H. Cheng,

    1. Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
    2. Key Lab of Dermatology, Ministry of Education, Hefei, Anhui, China
    3. State Key Lab Incubation of Dermatology, Ministry of Science and Technology, Hefei, Anhui, China
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  • W.-D. Du,

    1. Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
    2. Key Lab of Dermatology, Ministry of Education, Hefei, Anhui, China
    3. State Key Lab Incubation of Dermatology, Ministry of Science and Technology, Hefei, Anhui, China
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  • F.-Y. Zhang,

    1. Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
    2. Key Lab of Dermatology, Ministry of Education, Hefei, Anhui, China
    3. State Key Lab Incubation of Dermatology, Ministry of Science and Technology, Hefei, Anhui, China
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  • S. Yang,

    1. Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
    2. Key Lab of Dermatology, Ministry of Education, Hefei, Anhui, China
    3. State Key Lab Incubation of Dermatology, Ministry of Science and Technology, Hefei, Anhui, China
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  • X.-J. Zhang

    Corresponding author
    1. Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
    2. Key Lab of Dermatology, Ministry of Education, Hefei, Anhui, China
    3. State Key Lab Incubation of Dermatology, Ministry of Science and Technology, Hefei, Anhui, China
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  • Conflict of Interest
    The authors declare no conflict of interests.

  • Funding Sources
    This study was supported by Youth Project (81000692) and Normal Project (30971644) of National Natural Science Foundation of China, Anhui High Education Project (KJ2010B402), Anhui Province Natural Science Foundation (1208085QH145) and Chinese Society of Dermatology LEO Foundation.

X-Y Yin and Prof. X-J Zhang. E-mails:xianyongyin@gmail.com, ayzxj@vip.sina.com

Abstract

Background  Psoriasis is a common chronic inflammatory skin disease. IL23/Th17 is a newly confirmed pathway in psoriasis.

Objective  To investigate the gene–gene interactions in IL23/Th17 pathway underlying psoriasis.

Methods  A total of 299 single-nucleotide polymorphisms from 11 genes in IL23/Th17 pathway were genotyped on 1139 patients with psoriasis and 1694 controls. Multifactor dimensionality reduction and logistic regression algorithms were applied to explore the gene–gene interactions.

Results  We found that there were a three-way interaction among IL21, CCR4 and TNF(χ2 = 5.02(1), P = 0.025) and three pair-wise gene–gene interactions between IL12RB1 and CCR4(χ2 = 11.66(4), P = 0.0201), IL22 and CCR4 (χ2 = 11.97(4), P = 0.0176), IL12RB1 and IL6 (χ2 = 7.31(1), P = 0.0069) in psoriasis.

Conclusions  Our results might be helpful for explaining the missing heritability of the psoriasis due to epistasis and provide a deep insight into the important role of the IL23/Th17 pathway in the pathogenesis of psoriasis.

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