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Therapeutic implications of adding the psychotropic drug escitalopram in the treatment of patients suffering from moderate–severe psoriasis and psychiatric comorbidity: a retrospective study


  • Conflict of interest
    The authors declare no affiliation or significant financial involvement in any organizations or entity with a direct financial interest in the subject matter or materials discussed in the manuscript on this page.


Background  It is known that stress and/or psychiatric diseases can play an important role in determining psoriasis, including the well-known negative somato–psychiatric rebound that comes with the disease.

Methods  Samples of 38 subjects suffering from both moderate–severe psoriasis treated with anti-TNFα, and depressive and/or anxious mood disorders were studied. Part of them were additionally treated with escitalopram, whereas the other group only consulted to a dermatological and psychiatric follow-up.

The aim of this study was to determine if an improvement in the dermatological manifestation as well as an improvement in the anxious–depressive disorder can be observed.

Results  The study revealed that patients treated with escitalopram had a reduction of psycho-diagnostic test scores that measure depression and anxiety levels as well as the values of pruritus.

Conclusion  Our study suggests that psychological interventions and antidepressant medications may improve perceived symptom severity, quality of life and major compliance to the treatment in selected patients (suffering from psoriasis and mood disturbance), without a clinician necessarily being able to see an impact on psoriasis severity.