Conflict of Interest Dr. Qureshi serves as a consultant to the Centers for Disease Control and Novartis. Drs. Dominguez, Han, Li and Ascherio have no conflicts of interest to declare. The authors have not published or submitted any related papers from this study.
Depression and the risk of psoriasis in US women
Article first published online: 3 OCT 2012
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
Volume 27, Issue 9, pages 1163–1167, September 2013
How to Cite
Dominguez, P.L., Han, J., Li, T., Ascherio, A. and Qureshi, A.A. (2013), Depression and the risk of psoriasis in US women. Journal of the European Academy of Dermatology and Venereology, 27: 1163–1167. doi: 10.1111/j.1468-3083.2012.04703.x
Funding sources This study was supported in part by a grant from the Department of Dermatology, Brigham and Women’s Hospital to AAQ. The NHSII cohort follow-up is funded by NIH CA50385.
- Issue published online: 28 JUL 2013
- Article first published online: 3 OCT 2012
- Received: 6 May 2012; Accepted: 17 August 2012
Background Depression is a common mental health condition that has been associated with psoriasis. In the absence of prospective data, it remains unclear whether depression precedes psoriasis as a risk factor.
Objectives To examine the association between depression and the risk of new-onset psoriasis.
Methods A prospective cohort of 86 880 US female nurses, The Nurses’ Health Study II, was followed up from 1993 to 2005. Participants reported anti-depressant use and completed the Mental Health Index (MHI), a subscale of the Short-Form 36 in 1993. The MHI assessed for depression and scores was categorized into four strata: 0–52, 53–75, 76–85 and 86–100, with lower scores associated with increasing depressive symptoms. We excluded participants with a history of psoriasis prior to 1993. A self-report of incident physician-diagnosed psoriasis constituted the main outcome measure. For a sensitivity analysis, we had a subset of confirmed psoriasis cases.
Results Depression was associated with an increased risk of incident psoriasis. Compared to women in the non-depressed group (MHI 86–100), women who reported either having high depressive symptomatology (MHI scores <52) or who were on anti-depressants had a multivariate relative risk (RR) of 1.59 for developing subsequent psoriasis (95% confidence interval [CI], 1.21–2.08). These associations became stronger among confirmed psoriasis cases.
Conclusions We found that depression was independently associated with an increased risk of psoriasis in this population of US women.