Is TNF-α a prognostic factor in patients with sepsis?
Article first published online: 2 JUN 2009
1997 European Society of Clinical Microbiology and Infectious Diseases
Clinical Microbiology and Infection
Volume 3, Issue 1, pages 24–31, February 1997
How to Cite
Schaumann, R., Schlick, T., Schaper, M. and Shah, P. M. (1997), Is TNF-α a prognostic factor in patients with sepsis?. Clinical Microbiology and Infection, 3: 24–31. doi: 10.1111/j.1469-0691.1997.tb00247.x
- Issue published online: 2 JUN 2009
- Article first published online: 2 JUN 2009
- Accepted 17 August 1996
- microbiologically documented and non-documented infections;
Objective: To determine tumor necrosis factor-α (TNF-α) levels in a prospective study in 58 hospitalized patients in a department of internal medicine (63 episodes, 29 in immunocompromised patients) during a 7-month period.
Method: Patients fulfilling the following criteria were included: clinical evidence of acute infection, temperature >38.2°C, tachycardia >90 beats/min, tachypnea >20 breaths/min. Samples were taken from day 1 up to day 13 after an infection was diagnosed, and TNF-α was determined by enzyme immunoassay.
Results: In 29 episodes (46.0%) the infection was microbiologically documented. The median of the TNF-α levels in the Gram-negative episodes was significantly higher than that in the Gram-positive episodes (p=0.002). Thirteen of 63 episodes (20.6%) had a fatal outcome. With respect to all measured values, the non-survivors had a significantly higher median of TNF-α levels than the survivors (p=0.0001). There was, however, great interpatient and intrapatient variability in TNF-α levels; thus, no unequivocal correlation between TNF-α and outcome could be documented.
Conclusions: Our data indicate that the influence of the infecting organism on TNF-α kinetics is less pronounced than that of the underlying disease.