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Macrolide-resistance mechanisms in Streptococcus pneumoniae isolates from Belgium

  1. J. Van Eldere1,
  2. E. Meekers1,
  3. K. Lagrou1,
  4. C. Massonet1,
  5. A. Canu2,
  6. I. Devenyns1,
  7. J. Verhaegen1,
  8. G. Syrogiannopoulos3,
  9. R. Leclercq2

Article first published online: 10 FEB 2005

DOI: 10.1111/j.1469-0691.2005.01077.x

Issue

Clinical Microbiology and Infection

Clinical Microbiology and Infection

Volume 11, Issue 4, pages 332–334, April 2005

Additional Information

How to Cite

Van Eldere, J., Meekers, E., Lagrou, K., Massonet, C., Canu, A., Devenyns, I., Verhaegen, J., Syrogiannopoulos, G. and Leclercq, R. (2005), Macrolide-resistance mechanisms in Streptococcus pneumoniae isolates from Belgium. Clinical Microbiology and Infection, 11: 332–334. doi: 10.1111/j.1469-0691.2005.01077.x

Author Information

  1. 1

    Department of Microbiology and Immunology, Katholieke Universiteit Leuven, Leuven, Belgium

  2. 2

    Laboratoire de Microbiologie, CHU de Caen, Caen, France

  3. 3

    Department of Paediatrics, General University Hospital, University of Patras, School of Medicine, Patras, Greece

*Corresponding author and reprint requests: J. Van Eldere, Laboratory of Bacteriology, CDG, 8th floor, UZ Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium E-mail: johan.vaneldere@uz.kuleuven.ac.be

Publication History

  1. Issue published online: 10 FEB 2005
  2. Article first published online: 10 FEB 2005
  3. Original Submission: 1 July 2004; Revised Submission: 25 October 2004; Accepted: 19 November 2004

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Keywords:

  • erm(B);
  • macrolide resistance;
  • mef(A);
  • pneumococci;
  • resistance;
  • Streptococcus pneumoniae

Abstract

Of 233 erythromycin-resistant pneumococcal isolates collected in Belgium in 1999–2000, 89.7% carried the erm(B) gene, 6% the mef(A) gene, and 3.5%erm(B) plus mef(A). Two isolates contained neither erm(B) nor mef(A); one contained an erm(A) subclass erm(TR) gene, while the other contained an A2058G mutation in domain V of the 23S rRNA gene. Of 209 erm(B)-positive isolates, 191 had clindamycin MICs > 16 mg/L and 18 had MICs ≤ 16 mg/L. Mef(A)-positive isolates all displayed the M resistance phenotype. Telithromycin remained active against erythromycin-resistant isolates, with the highest telithromycin MIC50 being found in mef(A)-positive isolates. No difference in the prevalence of different resistance mechanisms was observed compared to isolates collected in 1995–1997.

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