Clinical presentation of leptospirosis: a retrospective study of 34 patients admitted to a single institution in metropolitan France

Authors


Corresponding author and reprint requests: P. Tattevin, Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, 35033 Rennes Cedex, France
E-mail: pierre.tattevin@chu-rennes.fr

Abstract

Leptospirosis has a highly variable clinical presentation, which may be related to different infecting serovars, host factors, or a combination of these. This study investigated retrospectively 34 consecutive patients with serologically confirmed leptospirosis admitted during the period 1992–2002. On admission, the most frequent symptoms were fever (100%), headache (75%), myalgia (55%), arthralgia (45%) and vomiting (39%). Pertinent laboratory findings included lymphopenia (85%), thrombocytopenia (75%), elevated liver enzymes (87%) and renal abnormalities (proteinuria, 77%; haematuria, 58%; elevated serum creatinine, 53%). The study confirmed the variable clinical and biological symptoms of leptospirosis, and indicated that lymphopenia is a common feature of leptospirosis cases.

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