• 1
    Dinges MM, Orwin PM, Schlievert PM. Exotoxins of Staphylococcus aureus. Clin Microbiol Rev 2000; 13: 1634.
  • 2
    Waldvogel F. Staphylococcus aureus (including toxic shock syndrome). New York: Churchill Livingstone, 1995.
  • 3
    Witte W. Antibiotic resistance in gram-positive bacteria: epidemiological aspects. J Antimicrob Chemother 1999; 44 (suppl A): 19.
  • 4
    Stefani S, Varaldo PE. Epidemiology of methicillin-resistant staphylococci in Europe. Clin Microbiol Infect 2003; 9: 11791186.
  • 5
    Monecke S, Ehricht R. Rapid genotyping of methicillin-resistant Staphylococcus aureus (MRSA) isolates using miniaturised oligonucleotide arrays. Clin Microbiol Infect 2005; 11: 825833.
  • 6
    Kaneko J, Kamio Y. Bacterial two-component and hetero-heptameric pore-forming cytolytic toxins: structures, pore-forming mechanism, and organization of the genes. Biosci Biotechnol Biochem 2004; 68: 9811003.
  • 7
    Boubaker K, Diebold P, Blanc DS et al. Panton-Valentine leukocidin and staphyloccoccal skin infections in schoolchildren. Emerg Infect Dis 2004; 10: 121124.
  • 8
    Diep BA, Sensabaugh GF, Somboona NS et al. Widespread skin and soft-tissue infections due to two methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidin. J Clin Microbiol 2004; 42: 20802084.
  • 9
    Lina G, Piemont Y, Godail-Gamot F et al. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis 1999; 29: 11281132.
  • 10
    Monecke S, Slickers P, Hotzel H et al. Microarray-based characterisation of a Panton-Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect 2006; 12: 718728.
  • 11
    Vandenesch F, Naimi T, Enright MC et al. Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis 2003; 9: 978984.
  • 12
    Boussaud V, Parrot A, Mayaud C et al. Life-threatening hemoptysis in adults with community-acquired pneumonia due to Panton-Valentine leukocidin-secreting Staphylococcus aureus. Intens Care Med 2003; 29: 18401843.
  • 13
    Dufour P, Gillet Y, Bes M et al. Community-acquired methicillin-resistant Staphylococcus aureus infections in France: emergence of a single clone that produces Panton-Valentine leukocidin. Clin Infect Dis 2002; 35: 819824.
  • 14
    Francis JS, Doherty MC, Lopatin U et al. Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes. Clin Infect Dis 2005; 40: 100107.
  • 15
    Klein JL, Petrovic Z, Treacher D et al. Severe community-acquired pneumonia caused by Panton-Valentine leukocidin-positive Staphylococcus aureus: first reported case in the United Kingdom. Intens Care Med 2003; 29: 1399.
  • 16
    Van Der Flier M, Van Dijk NB, Fluit AC et al. Fatal pneumonia in an adolescent due to community-acquired methicillin-resistant Staphylococcus aureus positive for Panton-Valentine-leukocidin. Ned Tijdschr Geneeskd 2003; 147: 10761079.
  • 17
    Miller LG, Perdreau-Remington F, Rieg G et al. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med 2005; 352: 14451453.
  • 18
    Kravitz GR, Dries DJ, Peterson ML et al. Purpura fulminans due to Staphylococcus aureus. Clin Infect Dis 2005; 40: 941947.
  • 19
    Adem PV, Montgomery CP, Husain AN et al. Staphylococcus aureus sepsis and the Waterhouse–Friderichsen syndrome in children. N Engl J Med 2005; 353: 12451251.
  • 20
    Panton P, Valentine F. Staphylococcal toxin. Lancet 1932; i: 506508.
  • 21
    Robinson DA, Kearns AM, Holmes A et al. Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone. Lancet 2005; 365: 12561258.
  • 22
    Ender M, McCallum N, Adhikari R et al. Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus. Antimicrob Agents Chemother 2004; 48: 22952297.
  • 23
    Okuma K, Iwakawa K, Turnidge JD et al. Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol 2002; 40: 42894294.
  • 24
    Anonymous. Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus - Minnesota and North Dakota, 1997–99. JAMA 1999; 282: 11231125.
  • 25
    Baggett HC, Hennessy TW, Rudolph K et al. Community-onset methicillin-resistant Staphylococcus aureus associated with antibiotic use and the cytotoxin Panton-Valentine leukocidin during a furunculosis outbreak in rural Alaska. J Infect Dis 2004; 189: 15651573.
  • 26
    Ellis MW, Hospenthal DR, Dooley DP et al. Natural history of community-acquired methicillin-resistant Staphylococcus aureus colonization and infection in soldiers. Clin Infect Dis 2004; 39: 971979.
  • 27
    Shukla SK, Stemper ME, Ramaswamy SV et al. Molecular characteristics of nosocomial and native American community-associated methicillin-resistant Staphylococcus aureus clones from rural Wisconsin. J Clin Microbiol 2004; 42: 37523757.
  • 28
    Müller-Premru M, Strommenger B, Alikadic N et al. New strains of community-acquired methicillin-resistant Staphylococcus aureus with Panton-Valentine leukocidin causing an outbreak of severe soft tissue infection in a football team. Eur J Clin Microbiol Infect Dis 2005; 24: 848850.
  • 29
    Nguyen DM, Mascola L, Brancoft E. Recurring methicillin-resistant Staphylococcus aureus infections in a football team. Emerg Infect Dis 2005; 11: 526532.
  • 30
    Linde H, Wagenlehner F, Strommenger B et al. Healthcare-associated outbreaks and community-acquired infections due to MRSA carrying the Panton-Valentine leucocidin gene in southeastern Germany. Eur J Clin Microbiol Infect Dis 2005; 24: 419422.
  • 31
    Urth T, Juul G, Skov R et al. Spread of a methicillin-resistant Staphylococcus aureus ST80-IV clone in a Danish community. Infect Control Hosp Epidemiol 2005; 26: 144149.
  • 32
    Wannet W, Heck M, Pluister G et al. Panton-Valentine leukocidin positive MRSA in 2003: the Dutch situation. Euro Surveill 2004; 9: 2829.
  • 33
    Harmsen D, Claus H, Witte W et al. Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management. J Clin Microbiol 2003; 41: 54425448.
  • 34
    Enright MC, Day NPJ, Davies CE et al. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 2000; 38: 10081015.
  • 35
    Holmes A, Ganner M, McGuane S et al. Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease. J Clin Microbiol 2005; 43: 23842390.
  • 36
    Ehricht R, Slickers P, Goellner S et al. Optimized DNA microarray assay allows detection and genotyping of single PCR-amplifiable target copies. Mol Cell Probes 2006; 20: 6063.
  • 37
    Korczak B, Frey J, Schrenzel J et al. Use of diagnostic microarrays for determination of virulence gene patterns of Escherichia coli K1, a major cause of neonatal meningitis. J Clin Microbiol 2005; 43: 10241031.
  • 38
    Monecke S, Leube I, Ehricht R. Simple and robust array-based methods for the parallel detection of resistance genes of Staphylococcus aureus. Genome Lett 2003; 2: 106118.
  • 39
    Perreten V, Vorlet-Fawer L, Slickers P et al. Microarray-based detection of 90 antibiotic resistance genes of gram-positive bacteria. J Clin Microbiol 2005; 43: 22912302.
  • 40
    Sachse K, Hotzel H, Slickers P et al. DNA microarray-based detection and identification of Chlamydia and Chlamydophila spp. Mol Cell Probes 2005; 19: 4150.
  • 41
    Jarraud S, Mougel C, Thioulouse J et al. Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease. Infect Immun 2002; 70: 631641.
  • 42
    Ji G, Beavis R, Novick RP. Bacterial interference caused by autoinducing peptide variants. Science 1997; 276: 20272030.
  • 43
    Oliveira DC, Wu SW, De Lencastre H. Genetic organization of the downstream region of the mecA element in methicillin-resistant Staphylococcus aureus isolates carrying different polymorphisms of this region. Antimicrob Agents Chemother 2000; 44: 19061910.
  • 44
    Baba T, Takeuchi F, Kuroda M et al. Genome and virulence determinants of high virulence community-acquired MRSA. Lancet 2002; 359: 18191827.
  • 45
    Gill SR, Fouts DE, Archer GL et al. Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. J Bacteriol 2005; 187: 24262438.
  • 46
    Holden MTG, Feil EJ, Lindsay JA et al. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci USA 2004; 101: 97869791.
  • 47
    Kuroda M, Ohta T, Uchiyama I et al. Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet 2001; 357: 12251240.
  • 48
    Tenover FC, McDougal LK, Goering RV et al. Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United States. J Clin Microbiol 2006; 44: 108118.
  • 49
    Witte W, Braulke C, Cuny C et al. Emergence of methicillin-resistant Staphylococcus aureus with Panton-Valentine leukocidin genes in central Europe. Eur J Clin Microbiol Infect Dis 2005; 24: 15.
  • 50
    Coombs GW, Nimmo GR, Bell JM et al. Genetic diversity among community methicillin-resistant Staphylococcus aureus strains causing outpatient infections in Australia. J Clin Microbiol 2004; 42: 47354743.
  • 51
    Hanssen AM, Fossum A, Mikalsen J et al. Dissemination of community-acquired methicillin-resistant Staphylococcus aureus clones in northern Norway: sequence types 8 and 80 predominate. J Clin Microbiol 2005; 43: 21182124.
  • 52
    Kaneko J, Kimura T, Kawakami Y et al. Panton-Valentine leukocidin genes in a phage-like particle isolated from mitomycin C-treated Staphylococcus aureus V8 (ATCC 49775). Biosci Biotechnol Biochem 1997; 61: 19601962.
  • 53
    Kaneko J, Kimura T, Narita S et al. Complete nucleotide sequence and molecular characterization of the temperate staphylococcal bacteriophage phiPVL carrying Panton-Valentine leukocidin genes. Gene 1998; 215: 5767.
  • 54
    Narita S, Kaneko J, Chiba J et al. Phage conversion of Panton-Valentine leukocidin in Staphylococcus aureus: molecular analysis of a PVL-converting phage, phiSLT. Gene 2001; 268: 195206.
  • 55
    Maier J, Melzl H, Reischl U et al. Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus in Germany associated with travel or foreign family origin. Eur J Clin Microbiol Infect Dis 2005; 24: 637639.
  • 56
    Faria NA, Oliveira DC, Westh H et al. Epidemiology of emerging methicillin-resistant Staphylococcus aureus (MRSA) in Denmark: a nationwide study in a country with low prevalence of MRSA infection. J Clin Microbiol 2005; 43: 18361842.
  • 57
    Aires de Sousa M, Bartzavali C, Spiliopoulou I et al. Two international methicillin-resistant Staphylococcus aureus clones endemic in a University hospital in Patras, Greece. J Clin Microbiol 2003; 41: 20272032.
  • 58
    Iandolo JJ, Worrell V, Groicher KH et al. Comparative analysis of the genomes of the temperate bacteriophages [phi]11, [phi]12 and [phi]13 of Staphylococcus aureus 8325. Gene 2002; 289: 109118.
  • 59
    Darling C. Standardization and evaluation of the CAMP reaction for the prompt, presumptive identification of Streptococcus agalactiae (Lancefield group B) in clinical material. J Clin Microbiol 1975; 1: 171174.
  • 60
    Derbise A, De Cespedes G, El Solh N. Nucleotide sequence of the Staphylococcus aureus transposon, Tn5405, carrying aminoglycosides resistance genes. J Basic Microbiol 1997; 37: 379384.
  • 61
    O'Brien FG, Zaini Z, Coombs GW et al. Macrolide, lincosamide and streptogramin B resistance in a dominant clone of Australian community methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 2005; 56: 985986.
  • 62
    Robinson DA, Enright MC. Evolution of Staphylococcus aureus by large chromosomal replacements. J Bacteriol 2004; 186: 10601064.
  • 63
    Dunne WM. Panton-Valentine leukocidin genes in a laboratory quality control strain of Staphylococcus aureus. J Clin Microbiol 2006; 44: 287.
  • 64
    Garnier F, Tristan A, François B et al. Pneumonia and new methicillin-resistant Staphylococcus aureus clone. Emerg Infect Dis 2006; 12: 498500.