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Role of superantigenic strains in the prognosis of community-acquired methicillin-susceptible Staphylococcus aureus bacteraemia

  1. A. Desachy1,
  2. G. Lina2,
  3. P. Vignon1,
  4. A. Hashemzadeh1,
  5. F. Denis3,
  6. J. Etienne2,
  7. B. Francois1,
  8. M. C. Ploy3

Article first published online: 29 AUG 2007

DOI: 10.1111/j.1469-0691.2007.01810.x

Issue

Clinical Microbiology and Infection

Clinical Microbiology and Infection

Volume 13, Issue 11, pages 1131–1133, November 2007

Additional Information

How to Cite

Desachy, A., Lina, G., Vignon, P., Hashemzadeh, A., Denis, F., Etienne, J., Francois, B. and Ploy, M. C. (2007), Role of superantigenic strains in the prognosis of community-acquired methicillin-susceptible Staphylococcus aureus bacteraemia. Clinical Microbiology and Infection, 13: 1131–1133. doi: 10.1111/j.1469-0691.2007.01810.x

Author Information

  1. 1

    Dupuytren Teaching Hospital, Medical-Surgical Intensive Care Unit, Limoges

  2. 2

    INSERM, U851 and Université Lyon 1, Centre National de Référence des Staphylocoques, Faculté Laennec, Lyon

  3. 3

    Dupuytren Teaching Hospital, Department of Microbiology, Limoges, France

*Corresponding author and reprint requests: A. Desachy, Dupuytren Teaching Hospital, Medical-Surgical Intensive Care Unit, Limoges, France E-mail: arnaud.desachy@ch-angouleme.fr

Publication History

  1. Issue published online: 4 OCT 2007
  2. Article first published online: 29 AUG 2007
  3. Original Submission: 27 November 2006; Revised Submission: 19 June 2007; Accepted: 22 June 2007

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Keywords:

  • Bacteraemia;
  • cytokines;
  • methicillin-susceptible Staphylococcus aureus;
  • prognosis;
  • septic shock;
  • superantigenic toxins

Abstract

Methicillin-susceptible Staphylococcus aureus (MSSA) strains can produce superantigenic toxins that may trigger a massive release of pro-inflammatory cytokines, which are involved in the onset of septic shock. This 1-year prospective pilot study assessed the role of the production of superantigenic toxins in the outcome of immunocompetent patients hospitalised for community-acquired MSSA bacteraemia. Thirty-seven patients were enrolled, of whom 14 died in hospital. Fourteen patients had septic shock, and the mortality rate in this subgroup was 56%. Twenty-seven (73%) isolates produced at least one superantigenic toxin, but this did not influence the rate of occurrence of septic shock or death.

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