1469-0691/asset/bannerforeground.jpg?v=1&s=d64312ac8b913a4f04c6e0a755daba751d8d8d8d)
The spread of CTX-M-type extended-spectrum β-lactamases
Article first published online: 11 DEC 2007
DOI: 10.1111/j.1469-0691.2007.01867.x
© 2008 The Authors
Issue
Clinical Microbiology and Infection
Special Issue: ESBLs, Forever?
Volume 14, Issue Supplement s1, pages 33–41, January 2008
Additional Information
How to Cite
Rossolini, G. M., D’Andrea, M. M. and Mugnaioli, C. (2008), The spread of CTX-M-type extended-spectrum β-lactamases. Clinical Microbiology and Infection, 14: 33–41. doi: 10.1111/j.1469-0691.2007.01867.x
Publication History
- Issue published online: 11 DEC 2007
- Article first published online: 11 DEC 2007
- Abstract
- Article
- References
- Cited By
Keywords:
- CTX-M;
- Enterobacteriaceae;
- epidemiology;
- extended-spectrum β-lactamase;
- review
Abstract
CTX-M-type enzymes are a group of class A extended-spectrum β-lactamases (ESBLs) that are rapidly spreading among Enterobacteriaceae worldwide. More that 50 allotypes are known, clustered into six sub-lineages. The CTX-M-encoding genes have been captured from the chromosome of Kluyvera spp. on conjugative plasmids that mediate their dissemination among pathogenic enterobacteria. CTX-M-type ESBLs exhibit powerful activity against cefotaxime and ceftriaxone but generally not against ceftazidime, which has important implications for laboratory detection. However, several CTX-M variants with enhanced ceftazidimase activity have been detected. The rapid and massive spread of CTX-M-type ESBLs is rapidly changing the ESBL epidemiology and, in some geographical areas, these enzymes are now the most prevalent ESBLs in Enterobacteriaceae.