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Time-trends for Gram-negative and multidrug-resistant Gram-positive bacteria associated with nosocomial infections in German intensive care units between 2000 and 2005

  1. A. Kohlenberg1,2,
  2. F. Schwab1,2,
  3. C. Geffers1,2,
  4. M. Behnke1,2,
  5. H. Rüden1,2,
  6. P. Gastmeier2,3

Article first published online: 22 NOV 2007

DOI: 10.1111/j.1469-0691.2007.01879.x

Issue

Clinical Microbiology and Infection

Clinical Microbiology and Infection

Volume 14, Issue 1, pages 93–96, January 2008

Additional Information

How to Cite

Kohlenberg, A., Schwab, F., Geffers, C., Behnke, M., Rüden, H. and Gastmeier, P. (2008), Time-trends for Gram-negative and multidrug-resistant Gram-positive bacteria associated with nosocomial infections in German intensive care units between 2000 and 2005. Clinical Microbiology and Infection, 14: 93–96. doi: 10.1111/j.1469-0691.2007.01879.x

Author Information

  1. 1

    Institute of Hygiene and Environmental Medicine, Charité-University Medicine Berlin

  2. 2

    National Reference Center for Surveillance of Nosocomial Infections, Berlin

  3. 3

    Division of Hospital Epidemiology and Infection Control, Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany

*Corresponding author and reprint requests: A. Kohlenberg, Institute of Hygiene and Environmental Medicine, Charité-University Medicine Berlin, Heubnerweg 6, 14059 Berlin, Germany E-mail: anke.kohlenberg@charite.de

Publication History

  1. Issue published online: 22 NOV 2007
  2. Article first published online: 22 NOV 2007
  3. Original submission: 30 March 2007; Revised submission: 23 July 2007; Accepted: 17 August 2007

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Keywords:

  • German Nosocomial Infection Surveillance System;
  • intensive care units;
  • methicillin-resistant Staphylococcus aureus;
  • nosocomial infections;
  • surveillance;
  • time-trends

Abstract

This study analysed the time-trends for bacteria associated with nosocomial lower respiratory tract infections (LRTIs), bloodstream infections (BSIs) and urinary tract infections (UTIs) that were reported to the German Nosocomial Infection Surveillance System for intensive care units (ICUs). Data concerning 19 822 nosocomial infections were submitted by 139 ICUs between 2000 and 2005. There was a significant increase in the proportion of Gram-negative bacteria causing LRTIs (from 63.9% to 68.4%) and UTIs (from 65.3% to 68.6%). The proportion of BSIs caused by Gram-negative bacteria declined significantly, from 36.4% to 22.7%. The frequency of methicillin-resistant Staphylococcus aureus among all S. aureus isolates increased from 19.8% to 37.2%.

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