• 1
    Hanlon GW. The emergence of multidrug resistant Acinetobacter species: a major concern in the hospital setting. Lett Appl Microbiol 2005; 41: 375378.
  • 2
    Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN, Bonomo RA. Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 2007; 51: 34713484.
  • 3
    Poirel L, Nordmann P. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin Microbiol Infect 2006; 12: 826836.
  • 4
    Coelho JM, Turton JF, Kaufmann ME et al. Occurrence of carbapenem-resistant Acinetobacter baumannii clones at multiple hospitals in London and Southeast England. J Clin Microbiol 2006; 44: 36233627.
  • 5
    Zarrilli R, Casillo R, Di Popolo A et al. Molecular epidemiology of a clonal outbreak of multidrug-resistant Acinetobacter baumannii in a university hospital in Italy. Clin Microbiol Infect 2007; 13: 481489.
  • 6
    Poirel L, Nordmann P. Genetic structures at the origin of acquisition and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-58 in Acinetobacter baumannii. Antimicrob Agents Chemother 2006; 50: 14421448.
  • 7
    Turton JF, Ward ME, Woodford N et al. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol Lett 2006; 258: 7277.
  • 8
    Lee K, Ha GY, Shin BM et al. Metallo-β-lactamase-producing gram-negative bacilli in Korean Nationwide Surveillance of Antimicrobial Resistance group hospitals in 2003: continued prevalence of VIM-producing Pseudomonas spp. and increase of IMP-producing Acinetobacter spp. Diagn Microbiol Infect Dis 2004; 50: 5158.
  • 9
    Lee K, Yum JH, Yong D et al. Novel acquired metallo-beta-lactamase gene, blaSIM-1, in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea. Antimicrob Agents Chemother 2005; 49: 44854491.
  • 10
    Tsakris A, Ikonomidis A, Pournaras S et al. VIM-1 metallo-β-lactamase in Acinetobacter baumannii. Emerg Infect Dis 2006; 12: 981983.
  • 11
    Quale J, Bratu S, Landman D, Heddurshetti R. Molecular epidemiology and mechanisms of carbapenem resistance in Acinetobacter baumannii endemic in New York City. Clin Infect Dis 2003; 37: 214220.
  • 12
    Wroblewska MM, Towner KJ, Marchel H, Luczak M. Emergence and spread of carbapenem-resistant strains of Acinetobacter baumannii in a tertiary-care hospital in Poland. Clin Microbiol Infect 2007; 13: 490496.
  • 13
    Poirel L, Lebessi E, Heritier C, Patsoura A, Foustoukou M, Nordmann P. Nosocomial spread of OXA-58-positive carbapenem-resistant Acinetobacter baumannii isolates in a paediatric hospital in Greece. Clin Microbiol Infect 2006; 12: 11381141.
  • 14
    Pournaras S, Markogiannakis A, Ikonomidis A et al. Outbreak of multiple clones of imipenem-resistant Acinetobacter baumannii isolates expressing OXA-58 carbapenemase in an intensive care unit. J Antimicrob Chemother 2006; 57: 557561.
  • 15
    Tsakris A, Tsioni C, Pournaras S, Polyzos S, Maniatis AN, Sofianou D. Spread of low-level carbapenem-resistant Acinetobacter baumannii in a tertiary care Greek hospital. J Antimicrob Chemother 2003; 52: 10461047.
  • 16
    Levy MM, Fink MP, Marshall JC et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31: 12501256.
  • 17
    National Nosocomial Infections Surveillance System. National Nosocomial Infections Surveillance System report: data summary from January 1992 to June 2002. Am J Infect Control 2002; 30: 458475.
  • 18
    La Scola B, Gundi VA, Khamis A, Raoult D. Sequencing of the rpoB gene and flanking spacers for molecular identification of Acinetobacter species. J Clin Microbiol 2006; 44: 827832.
  • 19
    Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing, 17th informational supplement, M100-S17. Wayne, PA: CLSI, 2007.
  • 20
    Kaufmann ME, Pitt TL. Pulsed-field gel electrophoresis of bacterial DNA. In: ChartH, ed., Methods in practical laboratory bacteriology. London: CRC Press, 1994; 8392.
  • 21
    Tenover FC, Arbeit RD, Goering RV et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995; 33: 22332239.
  • 22
    Yan JJ, Hsueh PR, Ko WC et al. Metallo-β-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme. Antimicrob Agents Chemother 2001; 45: 22242228.
  • 23
    Tsakris A, Pournaras S, Woodford N et al. Outbreak of infections caused by Pseudomonas aeruginosa producing VIM-1 carbapenemase in Greece. J Clin Microbiol 2000; 38: 12901292.
  • 24
    Tognim MC, Gales AC, Penteado AP, Silbert S, Sader HS. Dissemination of IMP-1 metallo-β-lactamase-producing Acinetobacter species in a Brazilian teaching hospital. Infect Control Hosp Epidemiol 2006; 27: 742747.
  • 25
    Yong D, Choi YS, Roh KH et al. Increasing prevalence and diversity of metallo-β-lactamases in Pseudomonas spp., Acinetobacter spp., and Enterobacteriaceae from Korea. Antimicrob Agents Chemother 2006; 50: 18841886.
  • 26
    Lauretti L, Riccio ML, Mazzariol A et al. Cloning and characterization of blaVIM, a new integron-borne metallo-β-lactamase gene from a Pseudomonas aeruginosa clinical isolate. Antimicrob Agents Chemother 1999; 43: 15841590.
  • 27
    Miriagou V, Tzelepi E, Gianneli D, Tzouvelekis LS. Escherichia coli with a self-transferable, multiresistant plasmid coding for metallo-β-lactamase VIM-1. Antimicrob Agents Chemother 2003; 47: 395397.
  • 28
    Corbella X, Pujol M, Argerich MJ et al. Environmental sampling of Acinetobacter baumannii: moistened swabs versus moistened sterile gauze pads. Infect Control Hosp Epidemiol 1999; 20: 458460.
  • 29
    Pournaras S, Tsakris A, Maniati M, Tzouvelekis LS, Maniatis AN. Novel variant (blaVIM-4) of the metallo-β-lactamase gene blaVIM-1 in a clinical strain of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2002; 46: 40264028.
  • 30
    Pournaras S, Maniati M, Petinaki E et al. Hospital outbreak of multiple clones of Pseudomonas aeruginosa carrying the unrelated metallo-β-lactamase gene variants blaVIM-2 and blaVIM-4. J Antimicrob Chemother 2003; 51: 14091414.
  • 31
    Ktari S, Arlet G, Mnif B et al. Emergence of multidrug-resistant Klebsiella pneumoniae isolates producing VIM-4 metallo-β-lactamase, CTX-M-15 extended-spectrum β-lactamase, and CMY-4 AmpC β-lactamase in a Tunisian university hospital. Antimicrob Agents Chemother 2006; 50: 41984201.
  • 32
    Libisch B, Muzslay M, Gacs M et al. Molecular epidemiology of VIM-4 metallo-β-lactamase-producing Pseudomonas sp. isolates in Hungary. Antimicrob Agents Chemother 2006; 50: 42204223.
  • 33
    Luzzaro F, Docquier JD, Colinon C et al. Emergence in Klebsiella pneumoniae and Enterobacter cloacae clinical isolates of the VIM-4 metallo-β-lactamase encoded by a conjugative plasmid. Antimicrob Agents Chemother 2004; 48: 648650.
  • 34
    Peleg AY, Bell JM, Hofmeyr A, Wiese P. Inter-country transfer of Gram-negative organisms carrying the VIM-4 and OXA-58 carbapenem-hydrolysing enzymes. J Antimicrob Chemother 2006; 57: 794795.