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Hepatitis E virus as a newly identified cause of acute viral hepatitis during human immunodeficiency virus infection

  1. P. Colson1,2,
  2. C. Dhiver3,
  3. R. Gérolami4

Article first published online: 24 NOV 2008

DOI: 10.1111/j.1469-0691.2008.02102.x

Issue

Clinical Microbiology and Infection

Clinical Microbiology and Infection

Volume 14, Issue 12, pages 1176–1180, December 2008

Additional Information

How to Cite

Colson, P., Dhiver, C. and Gérolami, R. (2008), Hepatitis E virus as a newly identified cause of acute viral hepatitis during human immunodeficiency virus infection. Clinical Microbiology and Infection, 14: 1176–1180. doi: 10.1111/j.1469-0691.2008.02102.x

Author Information

  1. 1

    Laboratoire de Virologie, Fédération Hospitalière de Bactériologie-Virologie Clinique, Centre Hospitalier Universitaire Timone,

  2. 2

    URMITE CNRS-IRD UMR 6236, Faculté de Médecine et de Pharmacie, Université de la Méditerranée (Aix-Marseille-II),

  3. 3

    Service de Maladies Infectieuses, Centre Hospitalier Universitaire Conception

  4. 4

    Service d’Hépato-Gastro-Entérologie, Centre Hospitalier Universitaire Conception, Marseille, France

*Corresponding author and reprint requests: P. Colson, Laboratoire de Virologie, Fédération Hospitalière de Bactériologie-Virologie Clinique, Centre Hospitalier Universitaire Timone, 264 rue Saint-Pierre 13385, Marseille cedex 05, France E-mail: philippe.colson@ap-hm.fr

Publication History

  1. Issue published online: 9 DEC 2008
  2. Article first published online: 24 NOV 2008
  3. Original Submission: 30 May 2008; Revised Submission: 30 July 2008; Accepted: 7 August 2008 Edited by S. Cutler

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Keywords:

  • Acute hepatitis;
  • autochthonous hepatitis E;
  • hepatitis E virus;
  • HIV infection;
  • immunosuppression

Abstract

The recent description of chronic hepatitis E in organ transplant recipients deserves increased awareness in the context of hepatitis E virus (HEV) infection in immunocompromised individuals. Reported here is what is apparently the first PCR-documented case of acute hepatitis E in a human immunodeficiency virus (HIV)-1-infected patient. The CD4+ T-lymphocyte count was 246/mm3. The IgM anti-HEV antibody and HEV RNA tests results from serum were positive. Hepatitis was benign, and chronic HEV infection was ruled out. The HEV genotype was 3f. The patient did not report recent travel abroad. HEV should be tested in HIV-infected individuals presenting with acute hepatitis. HEV RNA detection is useful in diagnosing HEV infection and in monitoring recovery.

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