HCV has been shown to have a worldwide distribution, occurring among persons of all ages, genders, races and regions of the world. The socio-economic burden of HCV has not yet been defined in most countries. Where the epidemiology of hepatitis C has been studied, the consequences of chronic hepatitis C, HCC and end-stage liver cirrhosis have been shown to increasingly impact on national health systems . New infections still occur, because of the continued use of unscreened or inappropriately screened blood transfusions and blood products, the failure to sterilize medical equipment adequately, and the increase in intravenous drug use in previously unaffected areas. Global, regional and national monitoring will be necessary to evaluate results and address shortcomings. The quality and coverage of population-based HCV prevalence should be improved, by using: (i) a representative population sample; and (ii) accurate diagnostic tests. To better evaluate the incidence trends and burden of chronic disease, the prevalence of HCV infection should be stratified according to age, ethnicity and gender. Since the first publication in 1997 , published evidence for the prevalence of HCV still remains disappointedly limited, as information is still inadequate in many countries, most published prevalence studies being of limited scope, representing only a segment of the population [11–13] (e.g. pregnant women, blood donors or hospital admissions), with only a few studies using sampling techniques that represent the entire population.
Prevalence of hepatitis C worldwide
As most acute HCV infections (60–70%) are asymptomatic [14–16], data on the incidence of new cases of HCV infection are difficult to obtain and therefore scarce. Some risk groups, such as haemophiliacs, haemodialysis patients, patients transfused with unscreened blood and unscreened blood products, inmates of long-term correctional facilities, and persons with occupational exposure, clearly have a high incidence and prevalence of HCV infection [17–24].
As measurement of incidence fails to produce reliable numbers, because of the mostly asymptomatic form of acute infection, most approximations are based on reviews of published prevalence data, which estimated that 130–170 million persons, or 2–3% of the world’s population, are infected with HCV [25–27]. The current estimates are given in Fig. 1 and Tables 1 and 2. Prevalence estimates are 400 000 chronically infected subjects in Australia and Oceania, 14 million in the Americas, 16 million in the Middle East, 17.5 million in Europe, 28 million in Africa, and 83 million in Asia .
Table 1. Hepatitis C global prevalence country data 2010a
|Country||Anti-HCV (%)||No. infected|
|Antigua and Barbuda||0.75||525|
|Bosnia and Herzegovina||1.5||58 605|
|Brazil||1.4||2 609 670|
|Burkina Faso||5.2||846 924|
|Cameroon||13.8||2 754 204|
|Cape Verde||3||15 390|
|Central African Republic||2.4||108 144|
|China||2.2||29 791 212|
|Costa Rica||0.75||32 453|
|Czech Republic||1.5||153 300|
|Dominican Republic||0.75||66 713|
|Democratic Republic of Congo||6.4||4 010 240|
|Egypt||14||11 826 360|
|El Salvador||2.5||164 689|
|Equatorial Guinea||1.7||11 781|
|Ethiopia||1.9||1 500 734|
|Federal States of Micronesia||2||2200|
|India||1.5||18 216 960|
|Indonesia||3.9||9 436 986|
|Italy||3.2||1 923 136|
|Ivory Coast||3.3||717 783|
|Japan||2.4||3 058 008|
|Malawi||6.8||1 067 056|
|Mexico||1||1 106 450|
|New Zealand||0.3||11 820|
|Nigeria||2.1||3 323 439|
|North Korea||1||231 130|
|Pacific Islands (Palau)||2||606|
|Pakistan||5.9||9 422 403|
|Papua New Guinea||2||117 740|
|Philippines||2.2||1 932 854|
|Romania||4.5||1 003 680|
|Russia||4.1||5 796 498|
|Sao Tome and Principe||10||17 580|
|Saudi Arabia||1.8||437 292|
|Sierra Leone||2||117 680|
|South Africa||1.7||858 364|
|South Korea||1.68||823 956|
|Sri Lanka||1||207 180|
|St Kitts and Nevis||2.2||880|
|St Vincent and the Grenadines||1||1180|
|Sudan||2.8||1 209 376|
|Thailand||2.2||1 499 058|
|The Gambia||2.4||42 024|
|The Netherlands||1||163 360|
|Trinidad and Tobago||3.9||50 583|
|Turkey||2.2||1 549 108|
|Uganda||6.6||2 230 536|
|Ukraine||4||1 864 840|
|United Arab Emirates||2.3||81 052|
|United Republic of Tanzania||3.2||1 441 280|
|USA||1.8||5 367 834|
|Uzbekistan||6.5||1 774 955|
|Western Sahara||3||15 900|
|Total infected|| ||158 910 617|
|% population||2.35|| |
Table 2. Hepatitis C regional prevalence 2010
|Region||Anti-HCV (%)||No. HCV-infected|
|Africa||3.2||28 100 000|
|Americas||1.5||14 000 000|
|Asia||2.1||83 000 000|
|Australia and Oceania||1.2||400 000|
|Europe||2.3||17 500 000|
|Middle East||4.7||16 000 000|
|Total||2.35||159 000 000|
The published data suggest that most populations in the Americas, western Europe and Southeast Asia have prevalence rates of antibody to HCV (anti-HCV) under 2.5%. Anti-HCV prevalence rates for eastern Europe average from 1.5% to 5%, those for the Western Pacific region from 2.5% to 4.9%, and those for the Middle East and Central Asia from 1% to more than 12% . In terms of absolute numbers, the majority of infected people live in Central/Southeast Asia and the Western Pacific regions (Table 2), a finding similar to that for chronic hepatitis B infection.
Only a few studies on cost estimates are available. In the USA, the current estimate of the annual costs of acute and chronic hepatitis C exceeds US$600 million , and over the period 2010–2019, the total costs are expected to be US$184 billion , giving an indication of how important the burden of chronic HCV infection can be for national health systems, even in a low-endemicity country (1.8%). The European Monitoring Centre for Drugs and Drug Addiction estimated the HCV-related costs in ten European Union countries to be €50 million, excluding HCV drug therapy and monitoring, thereby demonstrating that, even with no public health action, HCV causes significant costs to society. The estimates for Spain were approximately €3 billion for the period 2010–2030 , and in Canada the costs are estimated at CD$150 million annually until 2040 .
As representative prevalence data are still not available from many countries, and progress since 1997 has been scarce, the local, national and regional baseline estimates of the rate of infection, the number of individuals chronically infected and the burden of disease are not established, making it impossible to assess correctly the impact of control and prevention measures. In addition, highly significant differences in subnational population groups have been documented.
For instance, in China, Bao et al.  found that the prevalence in non-injection drug users varied from 0% (Anhui) to 40.00% (Fujian). Intravenous drug use is increasing in China, posing a new challenge to public health authorities for the implementation of harm reduction programmes . Only a few studies have addressed the prevalence of HCV in China. In a cross-sectional study conducted in six different regions of the country, the overall prevalence of HCV was 0.58%, which was much lower than the 2.7% estimated by the WHO . On the other hand, the prevalence in the general population was found to be 2.1% in Fujian province , 9.6% in Henan province  and 25% in a rural community of elderly people . Therefore, in China, the geographical distribution of HCV infection is heterogeneous, and patterns differ between rural and urban settings, but, with the significant increase in intravenous drug use, it is expected that the prevalence will generally increase in China.
Hepatitis C is an emerging infection in India as well, and is already responsible for a significant proportion of liver disease in various states. However, the prevalence appears to be highly variable (‘patchy’), according to the geographical site or the population group analysed (0.09–7.89%) . Most of the studies of prevalence have been conducted in blood banks, and have shown prevalence rates of <2%, but in professional donors prevalence rates between 55.3% and 87.3% have been found. The consequences of chronic HCV infection will probably be significant increases in morbidity and mortality in India in the years to come.
Changing trends in HCV over the past 50 years have also been observed in Japan, where 70% of cases of HCC are attributable to HCV, and HCC is the fourth leading cause of death in males and the fifth in females. HCV started to spread in the 1930s among intravenous drug users (amphetamines) before, during and after World War II, or through medical procedures such as blood transfusion and the use of contaminated syringes. The prevalence of HCV infection is much lower in the younger generation than in the older generation aged >55 years (0.1–0.2% vs. >2%) . Therefore, the total number of patients with HCV infection is considered to have decreased. The incidence of HCC has steadily increased over the last 50 years, but it is now decreasing in Japan, mainly because of the decreased prevalence of HCV-related HCC. A similar trend has been observed in Italy [41,42].
Pakistan is a developing country of 170 million people, and recent investigations have shown that about 10 million (5.9%) people are presumed to be infected with HCV . Public health authorities are raising awareness about viral hepatitis among healthcare workers and the general population, but tremendous efforts are still required to combat various risk factors involved in HCV transmission, particularly because of the non-implementation of international standards regarding blood transfusion and safe injection practices.
Egypt has a very high prevalence of HCV, reaching as much as 32% in the population of young males requesting visas for foreign travel [44–47], and the country suffers high morbidity and mortality from chronic liver disease, cirrhosis and HCC. Approximately 20% of Egyptian blood donors are anti-HCV-positive . Geographically, the desert areas of Egypt have the lowest rates of anti-HCV positivity; rural areas tend to have higher rates than cities; and rates in the Nile Delta (Lower Egypt) are higher than in the Nile Valley (Middle Egypt and Upper Egypt) [44,46,47]. The strong homogeneity of HCV subtypes found in Egypt (mostly 4a) [48–50] suggests an epidemic spread of HCV . The risk factor(s) originally responsible for the establishment of HCV in the general population may not necessarily be the same as those responsible for transmitting the virus today. Therefore, both traditional risk factors and risk factors that may be unique to Egypt need to be considered in explaining the transmission of HCV in this country. The prime candidate to explain the high prevalence of HCV in Egypt is the past practice of parenteral therapy for schistosomiasis with tartar emetic (potassium antimony tartrate), and the data suggest that Egypt’s mass campaigns do indeed represent the world’s largest example of iatrogenic transmission of a blood-borne pathogen ; the large reservoir of chronic HCV infection established in the course of these campaigns remains the most likely reason for today’s high prevalence of HCV, which may be largely responsible for the continuing endemic transmission of HCV today . Egypt has a unique HCV prevalence pattern that is not comparable with those of its eastern Mediterranean neighbours. However, in the recent past, intravenous drug use has been shown to have increased in the Middle East, as documented for Iran . It is therefore expected that the prevalence of HCV will increase in the next 10 years.
For Africa, HCV prevalence data are incomplete, but show considerable variation from one population studied to another, with prevalence rates from 0% to 51% [54–57]. More than 28 million people are chronically infected with HCV on this continent. It is currently difficult to determine trends concerning current and future infection rates.
In Europe, too, the HCV prevalence data are often incomplete, outdated or inconclusive. The current estimates are that 7.3–8.8 million people (1.1–1.3%) are chronically infected in the European Union, a figure that is almost double the first estimates performed in 1997 , indicating that HCV is also a major health problem in Europe , and an increase is forecasted for the next decade [59–61]. For the whole of the European continent, it is estimated that 17.5 million individuals are infected. Recently, a 3-month pilot study carried out by the Hepatitis C Trust in pharmacies in England found that the prevalence of HCV infection was almost four times as high as previously estimated. The pilot study found a prevalence of 15%, which is significantly more than the 4% determined by tests carried out in general practitioner surgeries in 2008 , emphasizing that the study design has major consequences for outcomes in population-based studies, and calling for caution when evaluating published HCV prevalence figures, even in well-studied countries.
In addition to anti-HCV-based prevalence studies, longitudinal genotype observation adds a further tool for monitoring epidemiological trends. Measurement of the spatial introduction of new genotypes in a population, and the rate of sequence evolution or natural recombinations in viruses introduced at a given time in a cohort, provides the possibility of evaluating the history of the past geographical spread of HCV through different populations, shedding light on the demographic, social and biological factors that are at the basis of ancient and current unrecognized routes of transmission. Genotypes 1–3 have a worldwide distribution [48,63–65]. Genotypes 4 and 5 are found principally in Africa, and genotype 6 is distributed in Asia . Endemic areas for specific genotypes are found in West Africa (types 1 and 2), West Central Africa (type 4), the Indian subcontinent (type 3), Central Africa (type 4) and Southeast Asia (type 6). An endemic area for genotype 5 has not been found [49,67–73], except for a local county in central France, where HCV 5a contamination of the local population was associated with living in a rural area called Vic-le-Comte. Abergel et al. suggest that HCV 5a spread by an iatrogenic route before 1972, and then via transfusion to the whole county . When a limited diversity of HCV subtypes is found in a certain geographical area, it may be attributed to the recent introduction of HCV into the population, as was documented for Canada  or Australia . The molecular epidemiology of HCV genotype 2 points to West and Central Africa, mostly along the African Atlantic coast, as its endemic place of origin. Markov et al. have found an eastwards spread from the West African coast to Cameroon that took place over several centuries . Molecular clock analysis dates the common ancestor of HCV to Guinea-Bissau, around 1470 (1414–1582). Isolates from Madagascar and Martinique suggest that the historical slave trade and the possible parenteral HCV exposure during public health campaigns undertaken during the colonial era may have played a role in the dissemination of HCV genotypes 2a and 2c. In summary, the geographical distribution of HCV genotypes and the rate of genetic variation are consistent with the global distribution of HCV, and are compatible with a long history of infection in most populations of the world, preceding, in many geographical locations, the era of modern medicine by many centuries.
HCV-related cirrhosis and deaths from HCC are likely to increase dramatically within the next decade, e.g. in Australia [78,79], Canada , France , the UK [59–61] and the USA . Owing to the increase in intravenous drug use in China, India and the Middle East, increases are likely to occur within this decade in these regions too, and because China and India are the countries with the largest populations, a 1% increase in both would result in an additional 25 million HCV-infected subjects. If patients are left undiagnosed and untreated, the future burden of the disease for healthcare resources and society will be substantial. A declining burden in the years to come is expected only in Italy [42,83], Japan , South Korea  (accompanied by a decrease in the incidence of HCC in these two countries)  and the USA .