• 1
    Strle F, Stanek G. Clinical manifestations and diagnosis of Lyme borreliosis. Curr Probl Dermatol 2009; 37: 51110.
  • 2
    Barbour AG. Biological and social determinants of the Lyme disease problem. Infect Agents Dis 1992; 1: 5061.
  • 3
    Barbour AG, Fish D. The biological and social phenomenon of Lyme disease. Science 1993; 260: 16101616.
  • 4
    Burgdorfer W, Barbour AG, Hayes SF, Benach JL, Grunwaldt E, Davis JP. Lyme disease—a tick-borne spirochetosis? Science 1982; 216: 13171319.
  • 5
    Steere AC, Grodzicki RL, Kornblatt AN et al. The spirochetal etiology of Lyme disease. N Engl J Med 1983; 308: 733740.
  • 6
    Benach JL, Bosler EM, Hanrahan JP et al. Spirochetes isolated from the blood of two patients with Lyme disease. N Engl J Med 1983; 308: 740742.
  • 7
    Johnson RC, Schmid GP, Hyde WF, Steigerwaldt AG, Brenner DJ. Borrelia burgdorferi sp.nov: etiologic agent of Lyme disease. Int J Syst Bacteriol 1984; 34: 496497.
  • 8
    Stanek G, Wewalka G, Groh V, Neumann R, Kristoferitsch W. Differences between Lyme disease and European arthropod-borne Borrelia infections. Lancet 1985; 8425: 401.
  • 9
    Wilske B, Preac-Mursic V, Schierz G. Antigenic heterogeneity of European Borrelia burgdorferi strains isolated from patients and ticks. Lancet 1985; 8437: 1099.
  • 10
    Wilske B, Preac-Mursic V, Schierz G, Kühbeck R, Barbour AG, Kramer M. Antigenic variability of Borrelia burgdorferi. Ann N Y Acad Sci 1988; 539: 126143.
  • 11
    Wilske B, Anderson JF, Baranton G et al. Taxonomy of Borrelia spp. Scand J Infect Dis Suppl 1991; 77: 108129.
  • 12
    Baranton G, Postic D, Saint Girons I et al. Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov., and group VS461 associated with Lyme borreliosis. Int J Syst Bacteriol 1992; 42: 378383.
  • 13
    Welsh J, Pretzman C, Postic D, Saint Girons I, Baranton G, McClelland M. Genomic fingerprinting by arbitrarily primed polymerase chain reaction resolves Borrelia burgdorferi into three distinct phyletic groups. Int J Syst Bacteriol 1992; 42: 370377.
  • 14
    Canica MM, Nato F, du Merle L, Mazie JC, Baranton G, Postic D. Monoclonal antibodies for identification of Borrelia afzelii sp. nov. associated with late cutaneous manifestations of Lyme borreliosis. Scand J Infect Dis 1993; 25: 441448.
  • 15
    Belfaiza J, Postic D, Bellenger E, Baranton G, Girons IS. Genomic fingerprinting of Borrelia burgdorferi sensu lato by pulsed-field gel electrophoresis. J Clin Microbiol 1993; 31: 28732877.
  • 16
    Postic D, Belfaiza J, Isogai E, Saint Girons I, Grimont PA, Baranton G. A new genomic species in Borrelia burgdorferi sensu lato isolated from Japanese ticks. Res Microbiol 1993; 144: 467473.
  • 17
    Kawabata H, Masuzawa T, Yanagihara Y. Genomic analysis of Borrelia japonica sp. nov. isolated from Ixodes ovatus in Japan. Microbiol Immunol 1993; 37: 843848.
  • 18
    Schwartz JJ, Gazumyan A, Schwartz I. rRNA gene organization in the Lyme disease spirochete, Borrelia burgdorferi. J Bacteriol 1992; 174: 37573765.
  • 19
    Postic D, Assous MV, Grimont PA, Baranton G. Diversity of Borrelia burgdorferi sensu lato evidenced by restriction fragment length polymorphism of rrf (5S)–rrl (23S) intergenic spacer amplicons. Int J Syst Bacteriol 1994; 44: 743752.
  • 20
    Marconi RT, Liveris D, Schwartz I. Identification of novel insertion elements, restriction fragment length polymorphism patterns, and discontinuous 23S rRNA in Lyme disease spirochetes: phylogenetic analyses of rRNA genes and their intergenic spacers in Borrelia japonica sp. nov. and genomic group 21038 (Borrelia andersonii sp. nov.) isolates. J Clin Microbiol 1995; 33: 24272434.
  • 21
    Fukunaga M, Hamase A, Okada K, Nakao M. Borrelia tanukii sp. nov. and Borrelia turdae sp. nov. found from ixodid ticks in Japan: rapid species identification by 16S rRNA gene-targeted PCR analysis. Microbiol Immunol 1996; 40: 877881.
  • 22
    Foretz M, Postic D, Baranton G. Phylogenetic analysis of Borrelia burgdorferi sensu stricto by arbitrarily primed PCR and pulsed-field gel electrophoresis. Int J Syst Bacteriol 1997; 47: 1118.
  • 23
    Marti Ras N, Postic D, Foretz M, Baranton G. Borrelia burgdorferi sensu stricto, a bacterial species ‘made in the U.S.A.’? Int J Syst Bacteriol 1997; 47: 11121117.
  • 24
    Margos G, Gatewood AG, Aanensend DM et al. MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi. Proc Natl Acad Sci USA 2008; 105: 87308735.
  • 25
    Wang G, van Dam AP, Le Fleche A et al. Genetic and phenotypic analysis of Borrelia valaisiana sp. nov. (Borrelia genomic groups VS116 and M19). Int J Syst Bacteriol 1997; 47: 926932.
  • 26
    Le Fleche A, Postic D, Girardet K, Peter O, Baranton G. Characterization of Borrelia lusituniae sp. nov. by 16s ribosomal DNA sequence analysis. Int J Syst Bacteriol 1997; 47: 926932.
  • 27
    Postic D, Ras NM, Lane RS, Hendson M, Baranton G. Expanded diversity among Californian borrelia isolates and description of Borrelia bissettii sp. nov (formerly Borrelia group DN127). J Clin Microbiol 1998; 36: 34973504.
  • 28
    Baranton G, Marti Ras N, Postic D. Molecular epidemiology of the aetiological agents of Lyme borreliosis. Wien Klin Wochenschr 1998; 110: 850855.
  • 29
    Masuzawa T, Pan MJ, Kadosaka T et al. Characterization and identification of Borrelia isolates as Borrelia valaisiana in Taiwan and Kinmen Islands. Microbiol Immunol 2000; 44: 10031009.
  • 30
    Masuzawa T, Takada N, Kudeken M et al. Borrelia sinica sp. nov., a Lyme disease-related Borrelia species isolated in China. Int J Syst Evol Microbiol 2001; 51: 18171824.
  • 31
    Younsi H, Sarih M, Jouda F et al. Characterization of Borrelia lusitaniae isolates collected in Tunisia and Morocco. J Clin Microbiol 2005; 43: 15871593.
  • 32
    Richter D, Schlee DB, Allgöwer R, Matuschka FR. Relationships of a novel Lyme disease spirochete, Borrelia spielmani sp. nov., with its hosts in Central Europe. Appl Environ Microbiol 2004; 70: 64146419.
  • 33
    Richter D, Postic D, Sertour N, Livey I, Matuschka FR, Baranton G. Delineation of Borrelia burgdorferi sensu lato species by multilocus sequence analysis and confirmation of the delineation of Borrelia spielmanii sp. nov. Int J Syst Evol Microbiol 2006; 56: 873881.
  • 34
    Herzberger P, Siegel C, Skerka C et al. Human pathogenic Borrelia spielmanii sp. nov. resists complement-mediated killing by direct binding of immune regulators factor H and factor H-like protein 1. Infect Immun 2007; 75: 48174825.
  • 35
    Chu CY, Liu W, Jiang BG et al. Novel genospecies of Borrelia burgdorferi sensu lato from rodents and ticks in southwestern China. J Clin Microbiol 2008; 46: 31303133.
  • 36
    Postic D, Garnier M, Baranton G. Multilocus sequence analysis of atypical Borrelia burgdorferi sensu lato isolates—description of Borrelia californiensis sp. nov., and genomospecies 1 and 2. Int J Med Microbiol 2007; 297: 263271.
  • 37
    Rudenko N, Golovchenko M, Lin T, Gao L, Grubhoffer L, Oliver JH Jr. Delineation of a new species of the Borrelia burgdorferi sensu lato complex, Borrelia americana sp. nov. J Clin Microbiol 2009; 47: 38753880.
  • 38
    Rudenko N, Golovchenko M, Grubhoffer L, Oliver JH Jr. Borrelia carolinensis sp. nov., a new (14th) member of the Borrelia burgdorferi sensu lato complex from the southeastern region of the United States. J Clin Microbiol 2009; 47: 134141.
  • 39
    Rudenko N, Golovchenko M, Grubhoffer L, Oliver JH Jr. Borrelia carolinensis sp. nov., a new species of Borrelia burgdorferi sensu lato isolated from rodents and ticks from the southeastern United States. Int J Syst Evol Microbiol 2011; 61: 381383.
  • 40
    Wilske B, Preac-Mursic V, Göbel UB et al. An OspA serotyping system for Borrelia burgdorferi based on reactivity with monoclonal antibodies and OspA sequence analysis. J Clin Microbiol 1993; 31: 340350.
  • 41
    Margos G, Vollmer SA, Cornet M et al. A new Borrelia species defined by multilocus sequence analysis of housekeeping genes. Appl Environ Microbiol 2009; 75: 54105416.
  • 42
    Margos G, Hojgaard A, Lane RS et al. Multilocus sequence analysis of Borrelia bissettii strains from North America reveals a new Borrelia species, Borrelia kurtenbachii. Ticks Tick Borne Dis 2010; 1: 151158.
  • 43
    Wayne LG, Brenner DJ, Colwell RR et al. Report of the Ad Hoc Committee on Reconciliation of Approaches to Bacterial Systematics. Int J Syst Bacteriol 1987; 37: 463464.
  • 44
    Ruzic′-Sabljic′ E, Zore A, Strle F. Characterization of Borrelia burgdorferi sensu lato isolates by pulsed-field gel electrophoresis after MluI restriction of genomic DNA. Res Microbiol 2008; 159: 441448.
  • 45
    Cerar T, Ogrinc K, Cimperman J, Lotric-Furlan S, Strle F, Ruzić-Sabljić E. Validation of cultivation and PCR methods for diagnosis of Lyme neuroborreliosis. J Clin Microbiol 2008; 46: 33753379.
  • 46
    Wang G, van Dam AP, Schwartz I, Dankert J. Molecular typing of Borrelia burgdorferi sensu lato: taxonomic, epidemiological, and clinical implications. Clin Microbiol Rev 1999; 12: 633653.
  • 47
    Masuzawa T, Komikado T, Iwaki A, Suzuki H, Kaneda K, Yanagihara Y. Characterization of Borrelia sp. isolated from Ixodes tanuki, I. turdus, and I. columnae in Japan by restriction fragment length polymorphism of rrf (5S)–rrl (23S) intergenic spacer amplicons. FEMS Microbiol Lett 1996; 142: 7783.
  • 48
    Lin T, Oliver JH Jr, Gao L, Kollars TM Jr, Clark KL. Genetic heterogeneity of Borrelia burgdorferi sensu lato in the southern United States based on restriction fragment length polymorphism and sequence analysis. J Clin Microbiol 2001; 39: 25002507.
  • 49
    Liveris D, Gazumyan A, Schwartz I. Molecular typing of Borrelia burgdorferi sensu lato by PCR-restriction fragment length polymorphism analysis. J Clin Microbiol 1995; 33: 589595.
  • 50
    Liveris D, Wormser GP, Nowakowski J et al. Molecular typing of Borrelia burgdorferi from Lyme disease patients by PCR-restriction fragment length polymorphism analysis. J Clin Microbiol 1996; 34: 13061309.
  • 51
    Jones KL, Glickstein LJ, Damle N, Sikand VK, McHugh G, Steere AC. Borrelia burgdorferi genetic markers and disseminated disease in patients with early Lyme disease. J Clin Microbiol 2006; 44: 44074413.
  • 52
    Jones KL, McHugh GA, Glickstein LJ, Steere AC. Analysis of Borrelia burgdorferi genotypes in patients with Lyme arthritis: high frequency of ribosomal RNA intergenic spacer type 1 strains in antibiotic-refractory arthritis. Arthritis Rheum 2009; 60: 21742182.
  • 53
    Wormser GP, Liveris D, Nowakowski J et al. Association of specific subtypes of Borrelia burgdorferi with hematogenous dissemination in early Lyme disease. J Infect Dis 1999; 180: 720725.
  • 54
    Travinsky B, Bunikis J, Barbour AG. Geographic differences in genetic locus linkages for Borrelia burgdorferi. Emerg Infect Dis 2010; 16: 11471150.
  • 55
    Hanincová K, Liveris D, Sandigursky S, Wormser GP, Schwartz I. Borrelia burgdorferi sensu stricto is clonal in patients with early Lyme borreliosis. Appl Environ Microbiol 2008; 78: 50085014.
  • 56
    Gevers D, Cohan FM, Lawrence JG et al. Re-evaluating prokaryotic species. Nat Rev Microbiol 2005; 3: 733739.
  • 57
    Fingerle V, Schulte-Spechtel UC, Ruzic-Sabljic E et al. Epidemiological aspects and molecular characterization of Borrelia burgdorferi s.l. from southern Germany with special respect to the new species Borrelia spielmanii sp. nov. Int J Med Microbiol 2008; 298: 279290.
  • 58
    Rudenko N, Golovchenko M, Mokrácek A et al. Detection of Borrelia bissettii in cardiac valve tissue of a patient with endocarditis and aortic valve stenosis in the Czech Republic. J Clin Microbiol 2008; 46: 35403543.
  • 59
    Collares-Pereira M, Couceiro S, Franca I et al. First isolation of Borrelia lusitaniae from a human patient. J Clin Microbiol 2004; 42: 13161318.
  • 60
    Logar M, Ruzić-Sabljić E, Maraspin V et al. Comparison of erythema migrans caused by Borrelia afzelii and Borrelia garinii. Infection 2004; 32: 1519.
  • 61
    Strle F, Ružić-Sabljić E, Cimperman J, Lotricč-Furlan S, Maraspin V. Comparison of findings for patients with Borrelia garinii and Borrelia afzelii isolated from cerebrospinal fluid. Clin Infect Dis 2006; 43: 704710.
  • 62
    Liveris D, Varde S, Iyer R et al. Genetic diversity of Borrelia burgdorferi in Lyme disease patients as determined by culture versus direct PCR with clinical specimens. J Clin Microbiol 1999; 37: 565569.
  • 63
    Wormser GP, Brisson D, Liveris D et al. Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease. J Infect Dis 2008; 198: 13581364.
  • 64
    Ruzić-Sabljić E, Lotric-Furlan S, Maraspin V, Cimperman J, Pleterski-Rigler D, Strle F. Analysis of Borrelia burgdorferi sensu lato isolated from cerebrospinal fluid. APMIS 2001; 109: 707713.
  • 65
    Ruzic-Sabljic E, Arnez M, Logar M et al. Comparison of Borrelia burgdorferi sensu lato strains isolated from specimens obtained simultaneously from two different sites of infection in individual patients. J Clin Microbiol 2005; 43: 21942200.
  • 66
    Müllegger RR, Means TK, Shin JJ et al. Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma. Infect Immun 2007; 75: 46214628.
  • 67
    Maraspin V, Ogrinc K, Ružić-Sabljić E, Lotrič-Furlan S, Strle F. Isolation of Borrelia burgdorferi sensu lato from blood of adult patients with borrelial lymphocytoma, Lyme neuroborreliosis, Lyme arthritis and acrodermatitis chronica atrophicans. Infection 2011; 39: 3540.