Molecular epidemiology of multidrug-resistant strains of Mycobacterium tuberculosis


  • W Sougakoff

    1. National Reference Centre for Mycobacteria (CNR-MyRMA), Laboratoire de Bactériologie-Hygiène, UPMC, ER5, Faculté de Médecine Pitié-Salpêtrière, Paris, France
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Corresponding author: W. Sougakoff, Laboratoire de Bactériologie-Hygiène, UPMC ER5, Faculté de Médecine Pitié-Salpêtrière, 91 boulevard de l’Hôpital, 75634 Paris Cedex 13, France


Clin Microbiol Infect 2011; 17: 800–805


Genotyping of Mycobacterium tuberculosis has been extensively used for investigating epidemics of multidrug-resistant strains of M. tuberculosis, in order to identify the factors involved in the transmission of such strains and determine effective control programmes to limit their expansion at both the individual and population levels. Here, we review the methods currently used to study the molecular epidemiology of multidrug-resistant M. tuberculosis strains, and the insights provided by these techniques regarding global trends and the transmission dynamics of multidrug-resistant tuberculosis at a world scale.