In vitro and in vivo reduced fitness and virulence in ciprofloxacin-resistant Acinetobacter baumannii
Article first published online: 15 NOV 2011
© 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases
Clinical Microbiology and Infection
Volume 18, Issue 1, pages E1–E4, January 2012
How to Cite
Smani, Y., López-Rojas, R., Domínguez-Herrera, J., Docobo-Pérez, F., Martí, S., Vila, J. and Pachón, J. (2012), In vitro and in vivo reduced fitness and virulence in ciprofloxacin-resistant Acinetobacter baumannii. Clinical Microbiology and Infection, 18: E1–E4. doi: 10.1111/j.1469-0691.2011.03695.x
- Issue published online: 14 DEC 2011
- Article first published online: 15 NOV 2011
- Accepted manuscript online: 13 OCT 2011 08:29AM EST
- Original Submission: 11 July 2011; Revised Submission: 27 September 2011; Accepted: 6 October 2011 Editor: D. Raoult Article published online: 13 October 2011
Figure S1. One-day biofilm formation. Biofilm formation of Acinetobacter baumannii CipS and CipR is shown. Representative results of three independent experiments are shown and data are the means ± S.D. p <0.05: * between MHB and inoculated groups, † between inoculated groups.
Figure S2. Mortality curves. Mice were infected with three different inocula (8.3, 7.3, and 6.3 CFU/mL) of Acinetobacter baumannii 77wt strain (black lines) and its ciprofloxacin resistant mutant 77R strain (gray lines). Mortality curves are analysed by Kaplan-Meier survival analysis.
Table S1. In vitro activity of ciprofloxacin against Acinetobacter baumannii strains in the presence and absence of PAβN and reserpine.
Table S2. Seven-day mortality monitoring in a murine model of peritoneal sepsis. Mice were infected with three different inocula of Acinetobacter baumannii CipS and CipR.
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