These authors contributed equally.
Severity of Escherichia coli bacteraemia is independent of the intrinsic virulence of the strains assessed in a mouse model
Article first published online: 23 JAN 2012
© 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases
Clinical Microbiology and Infection
Volume 19, Issue 1, pages 85–90, January 2013
How to Cite
Landraud, L., Jauréguy, F., Frapy, E., Guigon, G., Gouriou, S., Carbonnelle, E., Clermont, O., Denamur, E., Picard, B., Lemichez, E., Brisse, S. and Nassif, X. (2013), Severity of Escherichia coli bacteraemia is independent of the intrinsic virulence of the strains assessed in a mouse model. Clinical Microbiology and Infection, 19: 85–90. doi: 10.1111/j.1469-0691.2011.03750.x
- Issue published online: 21 DEC 2012
- Article first published online: 23 JAN 2012
- Accepted manuscript online: 6 DEC 2011 11:18AM EST
- Original Submission: 28 July 2011; Revised Submission: 4 November 2011; Accepted: 30 November 2011 Editor: D. Raoult
- Escherichia coli ;
- mouse model;
- virulence factor
Extraintestinal pathogenic Escherichia coli (ExPEC) strains, a major cause of bacteraemia, typically belong to phylogenetic group B2 and express diverse accessory traits that contribute to virulence in mouse infection models. However, their high genomic diversity obscures the relationship between virulence factors and severity of infection in patients. In this study, we analysed concomitantly the strain’s expression of virulence in a mouse model, genomic determinants and the clinical severity of infection in 60 bacteraemic patients. We show that bacterial virulence based on an animal model study and virulence factor determination is not correlated with pejorative outcome of E. coli human blood infections.