ORIGINAL ARTICLE

Metagenomics and development of the gut microbiota in infants

  1. Y. Vallès1,
  2. M. J. Gosalbes1,2,
  3. L. E. de Vries3,4,
  4. J. J. Abellán1,2,
  5. M. P. Francino1,5

Article first published online: 31 MAY 2012

DOI: 10.1111/j.1469-0691.2012.03876.x

Issue

Clinical Microbiology and Infection

Clinical Microbiology and Infection

Special Issue: Microbiome: Deciphering the last human body organ. Editors: Andrés Moya, Rafael Cantón and Didier Raoult

Volume 18, Issue Supplement s4, pages 21–26, July 2012

Additional Information

How to Cite

Vallès, Y., Gosalbes, M. J., de Vries, L. E., Abellán, J. J. and Francino, M. P. (2012), Metagenomics and development of the gut microbiota in infants. Clinical Microbiology and Infection, 18: 21–26. doi: 10.1111/j.1469-0691.2012.03876.x

Author Information

  1. 1

     Unitat Mixta d’Investigació en Genòmica i Salut, Centre Superior d’Investigació en Salut Pública/UVEG-Institut Cavanilles, València, Spain

  2. 2

     CIBER en Epidemiología y Salud Pública (CIBEResp), Barcelona, Spain

  3. 3

     Department of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark

  4. 4

     National Food Institute, Technical University of Denmark, Lyngby, Denmark

  5. 5

     School of Natural Sciences, University of California Merced, CA, USA

*Corresponding author: M. P. Francino, Unitat Mixta d’Investigació en Genòmica i Salut, Centre Superior d’Investigació en Salut Pública/UVEG-Institut Cavanilles, Avda. de Catalunya 21, València 46020, Spain E-mail: francino_pil@gva.es

Publication History

  1. Issue published online: 31 MAY 2012
  2. Article first published online: 31 MAY 2012
  3. Original Submission: 15 February 2011; Revised Submission: 27 September 2011; Accepted: 27 September 2011 Editors: A. Moya, Rafael Cantón, and D. Raoult

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Keywords:

  • Antibiotics;
  • faeces;
  • intestinal microbiota;
  • meconium;
  • metagenomics

Clin Microbiol Infect 2012; 18 (Suppl. 4): 21–26

Abstract

The establishment of a balanced intestinal microbiota is essential for numerous aspects of human health, yet the microbial colonization of the gastrointestinal tract of infants is both complex and highly variable among individuals. In addition, the gastrointestinal tract microbiota is often exposed to antibiotics, and may be an important reservoir of resistant strains and of transferable resistance genes from early infancy. We are investigating by means of diverse metagenomic approaches several areas of microbiota development in infants, including the deployment of functional capabilities at the community level, the presence of antibiotic resistances and the population dynamics of the most abundant genera.

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