The first two authors contributed equally to the manuscript.
Antibiotic resistance patterns of Escherichia coli isolates from different aquatic environmental sources in León, Nicaragua
Version of Record online: 28 JUN 2012
© 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases
Clinical Microbiology and Infection
Volume 18, Issue 9, pages E347–E354, September 2012
How to Cite
Amaya, E., Reyes, D., Paniagua, M., Calderón, S., Rashid, M.-U., Colque, P., Kühn, I., Möllby, R., Weintraub, A. and Nord, C. E. (2012), Antibiotic resistance patterns of Escherichia coli isolates from different aquatic environmental sources in León, Nicaragua. Clinical Microbiology and Infection, 18: E347–E354. doi: 10.1111/j.1469-0691.2012.03930.x
- Issue online: 16 AUG 2012
- Version of Record online: 28 JUN 2012
- Accepted manuscript online: 6 JUN 2012 06:41AM EST
- Original Submission: 8 February 2012; Revised Submission: 20 April 2012; Accepted: 20 May 2012 , Editor: R. Cantón , Article published online: 6 June 2012
- extended-spectrum β-lactamase;
Clin Microbiol Infect 2012; 18: E347–E354
Antibiotic-resistant bacteria have emerged due to the selective pressure of antimicrobial use in humans and animals. Water plays an important role in dissemination of these organisms among humans, animals and the environment. We studied the antibiotic resistance patterns among 493 Escherichia coli isolates from different aquatic environmental sources collected from October 2008 to May 2009 in León, Nicaragua. High levels of antibiotic resistance were found in E. coli isolates in hospital sewage water and in eight of 87 well-water samples. Among the resistant isolates from the hospital sewage, ampicillin, chloramphenicol, ciprofloxacin, nalidixic acid, trimethoprim-sulphamethoxazole was the most common multi-resistance profile. Among the resistant isolates from the wells, 19% were resistant to ampicillin, ceftazidime, ceftriaxone, cefotaxime, chloramphenicol, ciprofloxacin, gentamicin, nalidixic acid and trimethoprim-sulphamethoxazole. E. coli producing ESBL and harbouring blaCTX-M genes were detected in one of the hospital sewage samples and in 26% of the resistant isolates from the well-water samples. The blaCTX-M-9 group was more prevalent in E. coli isolates from the hospital sewage samples and the blaCTX-M-1 group was more prevalent in the well-water samples.