RESEARCH NOTE

Metallo-β-lactamase-producing Pseudomonas aeruginosa in the Netherlands: the nationwide emergence of a single sequence type

  1. A. K. Van der Bij1,2,
  2. D. Van der Zwan1,
  3. G. Peirano3,
  4. J. A. Severin1,
  5. J. D. D. Pitout3,
  6. M. Van Westreenen1,
  7. W. H. F. Goessens1,
  8. on behalf of the MBL-PA surveillance study group†

Article first published online: 13 JUL 2012

DOI: 10.1111/j.1469-0691.2012.03969.x

Issue

Clinical Microbiology and Infection

Clinical Microbiology and Infection

Volume 18, Issue 9, pages E369–E372, September 2012

Additional Information

How to Cite

Van der Bij, A. K., Van der Zwan, D., Peirano, G., Severin, J. A., Pitout, J. D. D., Van Westreenen, M., Goessens, W. H. F. and on behalf of the MBL-PA surveillance study group (2012), Metallo-β-lactamase-producing Pseudomonas aeruginosa in the Netherlands: the nationwide emergence of a single sequence type. Clinical Microbiology and Infection, 18: E369–E372. doi: 10.1111/j.1469-0691.2012.03969.x

Author Information

  1. 1

     Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam

  2. 2

     Department of Microbiology, Reinier de Graaf Groep, Delft, the Netherlands

  3. 3

     Department of Pathology and Laboratory Medicine, Microbiology and Infectious Diseases, University of Calgary, Calgary, AB, Canada

  1. †

    See ‡ for the members of the MBL-PA surveillance study group.

* Corresponding author: A. K. Van der Bij, Department of Microbiology, Reinier de Graaf Hospital, PO Box 5011, 2600 GA Delft, the Netherlands E-mail: akke.van.der.bij@rivm.nl

  1. †

    See ‡ for the members of the MBL-PA surveillance study group.

Publication History

  1. Issue published online: 16 AUG 2012
  2. Article first published online: 13 JUL 2012
  3. Accepted manuscript online: 14 JUN 2012 12:16PM EST
  4. Original Submission: 5 March 2012; Revised Submission: 18 May 2012; Accepted: 10 June 2012 , Editor: R. Cantón , Article published online: 14 June 2012

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Keywords:

  • Antimicrobial resistance;
  • carbapenemase;
  • molecular epidemiology;
  • nosocomial transmission;
  • Pseudomonas aeruginosa

Clin Microbiol Infect 2012; 18: E369–E372

Abstract

Recently, the first outbreak of clonally related VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010–2011, which identified the presence of VIM-2 MBL-producing P. aeruginosa in 11 different hospitals. Genotyping by multiple-locus variable-number tandem-repeat analysis (MLVA) showed that the majority of the 82 MBL-producing isolates found belonged to a single MLVA type (n = 70, 85%), identified as ST111 by multilocus sequence typing (MLST). As MBL-producing isolates cause serious infections that are difficult to treat, the presence of clonally related isolates in various hospitals throughout the Netherlands is of nationwide concern.

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