• 2
    Galen Opera Omnia. Lipsiae, 1824. De tremore, Cap. XIII and IV, in which species of tremor are differentiated, occurs in, pp. 586593.]
  • 3
    Gaubius, H. D. Institutiones Pathologiae medicinalis. Leiden, 1758. [Gives probably the first description of the gait characteristic of Paralysis agitans, p. 398: “Est et, ubi musculi, recte quidem ad voluntatis nutum in actum concitati, injussa dein agilitate atque impetu non reprimendo motus suos accelerant, mentemque invitam praecurrunt. Vitium, loquelae musculis frequens, nee his solis tamen proprium: vidi enim, qui currere, non gradi, poterat.”].
  • 4
    Sauvages, F. B. Nosologie méthodique. Paris, 1771. Translated from the Latin by Nicolas. In the section entitled “Des Maladies Convulsives” the following occurs: “Il paroît qu'on doit rapporter au même genre de maladie une autre espèce très-rare que les auteurs n'ont pas aperçue, et que je ne crois pas pouvoir mieux appeller que du nom de scélotyrbe festinante ou festinie.” T. I, p. 798.]
  • 5
    Sylvius, F. Deleboe. Opera Medica. Amstelodami, 1780. [Sections V, XIX and XXV of the Section entitled “Praxeos Medicae Idea Nova,” pp. 291, 292, refer to the author's differentiation between tremors which occur on attempts at voluntary motion and those which occur whilst the body is at rest.].
  • 6
    Parkinson, J. An Essay on the Shaking Palsy. London, 1817.
  • 7
    Moxon, W. A Form of Trembling Palsy. Lancet, Vol. I 1879, pp. 35. London, 1879. Plate, fig. 6.
  • 8
    Leroux, P. D. Contribution à l'étude des causes de la paralysie agitante. Paris, 1880.
  • 9
    Berger Paralysis agitans” in Eulenburg's Real-Encyclopädie der gesammten Heilkunde, Bd. X. Wien and Leipzig, 1882. Hereditary cases of the disease are described, p. 323. Plate, figs. 2, 4, 9.
  • 10
    L'Hirondel, G. Antécédents et causes de la maladie de Parkinσon. Paris, 1883. [Said to refér to a case of Paralysis agitans in mother and daughter.].
  • 11
    Weber, L. Paralysis agitans and a Consideration of some Cases of this Disease. Journal of Nervous and Mental Diseases, Vol. XV, pp. 356365. New York, 1888. [The hereditary element, it is said, does not seem to play any rôle in Paralysis agitans, yet one case is reported in a male whose father and two brothers were similarly affected, also a second case in a male whose brother was affected.].
  • 12
    Boroherini, A. Delia Paralisi Agitante. Rivista Sperimentale di Freniatria e di Medicina Legale, Vol. XV, pp. 149. Reggio-Emilia, 1889. Plate, fig. 3.
  • 13
    BeAchet, E. Contribution à l'étude clinique des formes de la maladie de Parkinson. Paris, 1892. [Describes a case of Paralysis agitans in two sisters.].
  • 14
    Gowers, W. R. A Manual of Diseases of the Nervous System. 2nd Edn. London, 1893. For observations concerning the heredity of Paralysis agitans see, p. 637. Heredity can seldom be traced, perhaps in not more than 15. In one case… the patient's father and uncle had suffered from it…. The sister of one patient and the mother of another and in two other cases the father suffered also from Paralysis agitans.
  • 15
    Clerici, A. and Medea, E. La malattia di Parkinson e l'eredo-familiarità. Bollettino clinico-scientifico delta Poliambulanza di Milano.
  • 16
    Collins, J. and Muskens, L. J. J. A clinical study of twenty-four cases of Paralysis agitans. New York Medical Journal, Vol. lxx, pp. 4146. New York, 1899. [The following hereditary cases are reported: (1) An affected male had a father with Paralysis agitans, his mother and a maternal uncle died with some form of paralysis. (2) Paralysis agitans in a mother and in her son. (3) An affected male had a father and possibly a paternal uncle similarly affected. (4) An affected female had a father and a paternal aunt with Paralysis agitans.].
  • 17
    Siehr, P. H. Znvei Fälle von Paralysis agitans im jugendlichen Alter. Dissertation, Königsberg, 1899. [A brother and sister were affected, the onset of tremor being at the age of 13 for the brother and at 16 for the sister: the mother was hysterical.].
  • 18
    Bury, J. S. Two cases of Paralysis agitans in the same family in which improvement followed the administration of Hyoscine. Lancet, Vol. I for 1902, p. 1097. London, 1902. Plate, fig. 5.
  • 19
    Terrien Une famille de Parkinsonniens. Gazette médicate de Nantes, T. XXI, pp. 594598. Nantes, 1903. [Describes Paralysis agitans in a brother and sister and in a male first cousin; two nephews were showing certain symptoms which the recorder thought might well be the forerunners of the disease in them also.].
  • 20
    Hart, T. S. Paralysis agitans: some clinical observations based on the study of 219 cases seen at the Clinic of Professor M. Allen Starr. Journal of Nervous and Mental Diseases, Vol. XXXI, pp. 177188. New York, 1904. [In 16 of cases the disease was found to have occurred in relatives—in the mother six times, in the father three times, in three cases a sister was affected, in one case a brother and in one case a cousin.].
  • 21
    Oppenheim, H. Lehrbuch der Nervenkrankheiten. 4te Aufl. Berlin, 1905. [Paralysis agitans is described Bd. II, S. 1313–1329; the following hereditary cases are reported: (1) Two sisters with Paralysis agitans at a comparatively early age. (2) Patient and brother affected. (3) (in 5th Edn) Three sisters affected.].
  • 22
    Pennato, P. Morbo di Parkinson post-infettivo e famigliare. La Riforma medica, Vol. XXI, pp. 150154. Napoli, 1905. [A brother and sister were affected, no information is given of other members of the family.].
  • 23
    Ricca, S. Due casi di morbo di Parkinson atipici in fratelloe sorella. La Riforma medica, Vol. XXIV, pp. 106770. Napoli, 1908. Plate, fig. 11.
  • 24
    Bonhoeffer, K. Demonstration eines Kranken mit juveniler Paralysis agitans. Berliner klinische Wochenschrift, Bd. XLVIII, S. 1250. Berlin, 1911. [Two siblings were affected, the onset in each case was at the age of 18 years.].
  • 25
    Mendel, K. Ueber Paralysis agitans. Berlin, 1911. [Four hereditary cases are described in this monograph: (1) The patient and two of the grandfather's brothers were affected. (2) The patient, father and uncle were affected. (3 and 4) In both cases the disease occurred in patient and sister.].
  • 26
    Willige, H. Über Paralysis agitans im jugendlichen Alter. Zeitschrift f. d. ges. Neurologic u. Psychiatrie, Bd. IV, S. 520–587. Berlin, 1911.
  • 27
    GuUnther, H. Über Paralysis agitans. Deutsche Zeitschrift f. Nervenheilkunde, Bd. XLVII, S. 192–206. Leipzig, 1913. Plate, fig. 10.
  • 28
    Lundboro, H. Medizinisch-biologische Familien-Forschungen. Jena, 1913. [See Text, pp. 461–4, Atlas Plate XXXV.] Plate, fig. 7.
  • 29
    Busch, P. Parkinsonsche Krankheit und Unfall. Dissertation. Zerbst, 1914.
  • 30
    Hunt, J. Ramsay. Progressive Atrophy of the Globus pallidus. A system disease of the Paralysis agitans type characterised by atrophy of the motor cells of the corpus striatum. Brain, Vol. XL, pp. 58148. London, 1917.
  • 31
    Benedek, L. and CsoUrsz, K. Heredofamiliarität bei Paralysis agitans. Deutsche Zeitschrift f. Nervenheilkunde, Bd. LXXIX, S. 367–373. Leipzig, 1923. Plate, fig. 8.
  • 32
    Patrick, H. T. and Levy, D. M. Parkinson's Disease. A Clinical Study of one hundred and forty-six cases. Archives of Neurology and Psychiatry, Vol. VII, pp. 711720. Chicago, 1923.