Regional localization of 3 Y-derived sequences on the human X and Y chromosomes

Authors

  • J. WOLFE,

    1. *Cancer Research Campaign, Eukaryotic Molecular Genetics Research Group, Department of Biochemistry, Imperial College of Science and Technology, London SW1 2AZ
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  • R. P. ERICKSON,

    Corresponding author
    1. †Laboratory of Human Molecular Genetics, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
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  • P. W. J. RIGBY,

    1. *Cancer Research Campaign, Eukaryotic Molecular Genetics Research Group, Department of Biochemistry, Imperial College of Science and Technology, London SW1 2AZ
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  • P. N. GOODFELLOW

    1. †Laboratory of Human Molecular Genetics, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
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†Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, U.S.A.

Summary

The structure of the Y chromosome and the relationship between the human sex chromosomes have been studied using Y-derived sequences cloned in cosmids. Two probes recognize different unique sequences which map to the heterochromatic part of the long arm of the Y chromosome. A third sequence is shared by the long arm of the X chromosome and the euchromatic part of the Y chromosome. Thus homology between the sex chromosomes occurs outside the pairing region.

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