Breakpoint distribution in constitutional chromosome rearrangements with respect to fragile sites
Version of Record online: 28 SEP 2007
Annals of Human Genetics
Volume 51, Issue 4, pages 329–336, October 1987
How to Cite
PORFIRIO, B., DALLAPICCOLA, B. and TERRENATO, L. (1987), Breakpoint distribution in constitutional chromosome rearrangements with respect to fragile sites. Annals of Human Genetics, 51: 329–336. doi: 10.1111/j.1469-1809.1987.tb01067.x
- Issue online: 28 SEP 2007
- Version of Record online: 28 SEP 2007
In an attempt to investigate possible relationships between fragile site bands and chromosome abnormalities, we have analysed the distribution of 6391 breakpoints found in constitutional rearrangements.
Were relative band lengths to be ignored, a general trend for breaks to be located in fragile site bands would be confirmed. On the other hand, no difference was detected between bands with or without fragile sites if the probability of breakage for each single band is assumed to be proportional to its length. Nevertheless, a number of bands with a great excess of breakage events were identified.